Molecular and serological evidence of flea-associated typhus group and spotted fever group rickettsial infections in Madagascar

Autor: Allen L. Richards, Minoarisoa Rajerison, Rado J. L. Rakotonanahary, Alan Harrison, Alice N. Maina, Sandra Telfer, Ju Jiang
Přispěvatelé: Unité Peste - Plague Unit [Antananarivo, Madagascar], Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Université d'Antananarivo, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Viral and Rickettsial Diseases Department, U.S. Naval Medical Research, This research was supported by the Wellcome Trust (RCDF and Senior Fellowship to ST, #081705 and #095171), the Institut Pasteur de Madagascar, and the Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center[847705.82000.25GB.A0074]
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
animal diseases
Rickettsioses
Rodent Diseases
MESH: Madagascar
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
11. Sustainability
MESH: Antibodies
Bacterial
Prevalence
MESH: Animals
Rickettsia
MESH: Phylogeny
Rocky Mountain Spotted Fever
Phylogeny
MESH: Middle Aged
biology
Middle Aged
Antibodies
Bacterial
3. Good health
MESH: Shrews
Infectious Diseases
Fleas
MESH: Young Adult
Siphonaptera
Female
Flea-borne spotted fever
Typhus
Epidemic Louse-Borne
Adult
MESH: Rats
030106 microbiology
030231 tropical medicine
Short Report
MESH: Insect Vectors
Murine typhus
03 medical and health sciences
Young Adult
Rickettsia typhi
parasitic diseases
medicine
Madagascar
Animals
Humans
MESH: Typhus
Epidemic Louse-Borne
MESH: Humans
Shrews
MESH: Adult
MESH: Siphonaptera
MESH: Rickettsia
biology.organism_classification
medicine.disease
bacterial infections and mycoses
Rickettsia felis
Virology
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
MESH: Male
Spotted fever
Insect Vectors
Rats
Pulex
MESH: Rocky Mountain Spotted Fever
bacteria
Parasitology
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
MESH: Rodent Diseases
MESH: Female
Typhus
Zdroj: Parasites and Vectors
Parasites and Vectors, BioMed Central, 2017, 10 (1), pp.125. ⟨10.1186/s13071-017-2061-4⟩
Parasites & Vectors
ISSN: 1756-3305
DOI: 10.1186/s13071-017-2061-4⟩
Popis: International audience; Background: Rickettsiae are obligate intracellular bacteria responsible for many febrile syndromes around the world,including in sub-Saharan Africa. Vectors of these pathogens include ticks, lice, mites and fleas. In order to assessexposure to flea-associated Rickettsia species in Madagascar, human and small mammal samples from an urbanand a rural area, and their associated fleas were tested.Results: Anti-typhus group (TGR)- and anti-spotted fever group rickettsiae (SFGR)-specific IgG were detected in24 (39%) and 21 (34%) of 62 human serum samples, respectively, using indirect ELISAs, with six individuals seropositivefor both. Only two (2%) Rattus rattus out of 86 small mammals presented antibodies against TGR. Out of 117fleas collected from small mammals, Rickettsia typhi, a TGR, was detected in 26 Xenopsylla cheopis (24%) collected fromrodents of an urban area (n = 107), while two of these urban X. cheopis (2%) were positive for Rickettsia felis, a SFGR. R.felis DNA was also detected in eight (31%) out of 26 Pulex irritans fleas.Conclusions: The general population in Madagascar are exposed to rickettsiae, and two flea-associated Rickettsiapathogens, R. typhi and R. felis, are present near or in homes. Although our results are from a single district, theydemonstrate that rickettsiae should be considered as potential agents of undifferentiated fever in Madagascar.
Databáze: OpenAIRE
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