Leukocyte count and bronchial hyperresponsiveness
| Autor: | Isabella Annesi, Francine Kauffmann, Elisabeth Orvoen-Frija, Marie-Pierre Oryszczyn, Françoise Neukirch, Joseph Lellouch |
|---|---|
| Přispěvatelé: | Annesi-Maesano, Isabella, Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe de Recherche en Informatique, Image et Instrumentation de Caen (GREYC), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 1988 |
| Předmět: |
Hypersensitivity
Immediate Male MESH: Methacholine Compounds Chronic bronchitis MESH: Asthma Common Cold Atopy Leukocyte Count 0302 clinical medicine Risk Factors MESH: Risk Factors Immunopathology Immunology and Allergy 030212 general & internal medicine Methacholine Chloride education.field_of_study MESH: Middle Aged Respiratory disease Smoking Middle Aged 3. Good health MESH: Respiratory Hypersensitivity Bronchial hyperresponsiveness MESH: Hypersensitivity Immediate medicine.drug Adult MESH: Smoking Immunology Population Bronchial Provocation Tests MESH: Bronchial Provocation Tests 03 medical and health sciences MESH: Methacholine Chloride medicine Respiratory Hypersensitivity Humans Methacholine Compounds education Asthma MESH: Humans business.industry MESH: Adult medicine.disease MESH: Male 030228 respiratory system [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Leukocyte Count Methacholine [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Common Cold |
| Zdroj: | Journal of Allergy and Clinical Immunology Journal of Allergy and Clinical Immunology, Elsevier, 1988, 82 (6), pp.1006-11 Journal of Allergy and Clinical Immunology, 1988, 82 (6), pp.1006-11 |
| ISSN: | 0091-6749 |
| Popis: | International audience; The relationship of total and differential blood leukocyte counts with bronchial methacholine response was studied in a population-based sample of 324 men. Geometric mean total leukocyte counts were significantly higher in reactors (6567 cells/mm3) than in nonreactors (5732 cells/mm3; p = 0.003). After adjusting for smoking habits, a factor contributing to both an elevation in peripheral leukocyte count and an increased level of airway responsiveness, reactor status remained significantly associated with leukocyte count. This association also persisted after controlling, with a logistic model, for atopy and common cold (marker of infection) and after excluding men with a history of asthma, chronic bronchitis, or low FEV1. Study of the differential leukocyte counts has shown that an increase was present for almost every type of leukocyte, and particularly evident for neutrophils. Whether these findings reflect an association between bronchial hyperresponsiveness and cellular inflammation needs more investigation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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