Regulation of memory CD4 T-cell pool size and function by natural killer T cells in vivo
| Autor: | Yusuke Endo, Damon J. Tumes, Kazuyoshi Kawahara, Yukiko Watanabe, Chiaki Iwamura, Shinichiro Motohashi, Kenta Shinoda, Yuki Kinjo, Toshinori Nakayama |
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| Přispěvatelé: | Iwamura, Chiaki, Shinoda, Kenta, Endo, Yusuke, Watanabe, Yukiko, Tumes, Damon John, Motohashi, Shinichiro, Kawahara, Kazuyoshi, Kinjo, Yuki, Nakayama, Toshinori |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
CD4-Positive T-Lymphocytes
CD1 Biology Interleukin 21 Interferon-gamma Mice Th2 Cells Cytotoxic T cell Animals alpha-galactosylceramide IL-2 receptor STAT5 Cell Proliferation Inflammation Mice Knockout Multidisciplinary CD40 Sulfoglycosphingolipids ZAP70 J alpha 18 KO mice Biological Sciences allergy Natural killer T cell CD1d KO mice Cell biology Killer Cells Natural biology.protein Interleukin 12 Interleukin-2 Interleukin-4 Antigens CD1d Glycolipids Immunologic Memory |
| Popis: | To develop more effective vaccines and strategies to regulate chronic inflammatory diseases, it is important to understand the mechanisms of immunological memory. Factors regulating memory CD4 + T helper (Th)-cell pool size and function remain unclear, however. We show that activation of type I invariant natural killer T (iNKT) cells with glycolipid ligands and activation of type II natural killer T (NKT) cells with the endogenous ligand sulfatide induced dramatic proliferation and expansion of memory, but not naïve, CD4 T cells. NKT cell-induced proliferation of memory Th1 and Th2 cells was dependent largely on the production of IL-2, with Th2-cell proliferation also affected by loss of IL-4. Type II NKT cells were also required for efficient maintenance of memory CD4 T cells in vivo. Activation of iNKT cells resulted in up-regulation of IFN-γ expression by memory Th2 cells. These IFN-γ–producing memory Th2 cells showed a decreased capability to induce Th2 cytokines and eosinophilic airway inflammation. Thus, activated NKT cells directly regulate memory CD4 T-cell pool size and function via the production of cytokines in vivo. |
| Databáze: | OpenAIRE |
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