Association of epicardial adipose tissue with serum level of cystatin C in type 2 diabetes

Autor: Kunihiro Yoshioka, Rieko Nakano, Kan Nagasawa, Yusuke Todate, Noriko Takebe, Tomomi Murai, Riyuki Nakagawa, Yutaka Hasegawa, Yasushi Ishigaki, Yoshihiko Takahashi, Mari Hangai
Rok vydání: 2017
Předmět:
Male
Leptin
Physiology
Peptide Hormones
Adipose tissue
lcsh:Medicine
Blood Pressure
Type 2 diabetes
Coronary Artery Disease
030204 cardiovascular system & hematology
Vascular Medicine
Biochemistry
Diagnostic Radiology
Fats
0302 clinical medicine
Immune Physiology
Medicine and Health Sciences
Coronary Heart Disease
lcsh:Science
Tomography
Innate Immune System
Multidisciplinary
biology
Radiology and Imaging
digestive
oral
and skin physiology
Middle Aged
Lipids
Cholesterol
Adipose Tissue
Hypertension
Cytokines
Female
Adiponectin
Pericardium
Research Article
Adult
medicine.medical_specialty
Imaging Techniques
Immunology
Cardiology
030209 endocrinology & metabolism
Neuroimaging
Research and Analysis Methods
Diabetes Complications
03 medical and health sciences
Adipokines
Diagnostic Medicine
Internal medicine
Diabetes mellitus
medicine
Humans
Cystatin C
Aged
business.industry
lcsh:R
Biology and Life Sciences
Molecular Development
medicine.disease
Atherosclerosis
Obesity
Hormones
Computed Axial Tomography
Endocrinology
Diabetes Mellitus
Type 2
Immune System
biology.protein
lcsh:Q
business
Tomography
X-Ray Computed
Body mass index
Biomarkers
Developmental Biology
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0184723 (2017)
ISSN: 1932-6203
Popis: Objective Accumulation of epicardial adipose tissue (EAT) is considered to be a cardiovascular risk factor independent from visceral adiposity, obesity, hypertension and diabetes. We explored the parameters related to EAT accumulation, aiming to clarify the novel pathophysiological roles of EAT in subjects with type 2 diabetes (T2DM). Methods We examined the laboratory values, including cystatinC, and surrogate markers used for evaluating atherosclerosis. EAT was measured as the sum of the adipose tissue area, obtained by plain computed tomography scans in 208 subjects with T2DM but no history of coronary artery disease. Results EAT correlated positively with age, body mass index (BMI), visceral fat area, leptin, cystatin C and C-peptide, while correlating negatively with adiponectin, estimated glomerular filteration rate (eGFR) and the liver-to-spleen ratio. Multiple linear regression analysis revealed serum cystatin C (β = 0.175), leptin (β = 0.536), BMI (β = 0.393) and age (β = 0.269) to be the only parameters showing independent statistically significant associations with EAT. When cystatin C was replaced with eGFR, eGFR showed no significant correlation with EAT. In reverse analysis, serum cystatin C was significantly associated with EAT after adjustment in multivariate analysis. Discussion EAT accumulation and elevated cystatin C have been independently regarded as risk factors influencing atherosclerosis. The strong association between EAT and cystatin C demonstrated herein indicates that EAT accumulation may play an important role in Cystatin C secretion, possibly contributing to cardiometabolic risk in T2DM patients.
Databáze: OpenAIRE
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