Cerebellar-parietal dysfunctions in multiple sclerosis patients with cerebellar signs
| Autor: | D. Pirritano, Carmelina Chiriaco, Antonio Cerasa, Graziella Mangone, Paola Valentino, Maria Cecilia Gioia, Paolo Perrotta, Aldo Quattrone, Luca Passamonti, Rita Nisticò |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cerebellum Posterior parietal cortex Neuropsychological Tests Multiple Sclerosis Relapsing-Remitting Developmental Neuroscience Cerebellar Diseases Parietal Lobe Image Interpretation Computer-Assisted Neural Pathways medicine Humans medicine.diagnostic_test Working memory Multiple sclerosis Cognition Magnetic resonance imaging Executive functions medicine.disease Magnetic Resonance Imaging Memory Short-Term medicine.anatomical_structure nervous system Neurology Female Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Experimental Neurology. 237:418-426 |
| ISSN: | 0014-4886 |
| Popis: | Consistent findings have shown that the cerebellum is critically implicated in a broad range of cognitive processes including executive functions. Of note, cerebellar symptoms and a number of cognitive deficits have been widely reported in patients with multiple sclerosis (MS). This study investigated for the first time the role of cerebellar symptoms in modulating the neural networks associated with a cognitive task broadly used in MS patients (Paced Visual Serial Addition Test (PVSAT)). Twelve relapsing-remitting (RR) MS patients with prevalent cerebellar signs and symptoms (RR-MSc), 15 RR-MS patients without cerebellar manifestation (RR-MSnc) and 16 matched-healthy controls were examined during functional magnetic resonance imaging (fMRI). We tested whether the RR-MSc patients displayed abnormal activations within "cognitive" cerebellar regions and other areas typically engaged in working memory and tightly connected with the cerebellum. Despite similar behavioral performances during fMRI, RR-MSc patients displayed, relatively to both RR-MSnc patients and controls, significantly greater responses in the left cerebellar Crus I/Lobule VI. RR-MSc patients also displayed reduced functional connectivity between the left cerebellar Crus I and the right superior parietal lobule (FWE |
| Databáze: | OpenAIRE |
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