Evaluation of deleted in malignant brain tumors 1 (DMBT1) gene expression in bladder carcinoma cases: Preliminary study

Autor: Yavuz Dodurga, Tahmina Bushra, Cigir Biray Avci, Canten Tataroglu, Zehra Kesen, Z. Ozlem Dogan, Cumhur Gündüz, N. Lale Satiroglu-Tufan, Sunde Yılmaz
Jazyk: angličtina
Rok vydání: 2011
Předmět:
bladder carcinoma
Male
Pathology
cancer patient
Health
Toxicology and Mutagenesis
Clinical Biochemistry
urologic and male genital diseases
Biochemistry
oncogene
transitional cell carcinoma
Gene expression
Aged
80 and over
Urinary bladder
evaluation
messenger RNA
Reverse Transcriptase Polymerase Chain Reaction
Bladder cancer
article
DBMT1 gene
gene expression regulation
Middle Aged
DNA-Binding Proteins
Gene Expression Regulation
Neoplastic
medicine.anatomical_structure
Transitional cell carcinoma
female
Mrna level
real-time online RT-PCR
cancer grading
histopathology
down regulation
DMBT1 gene
Adult
medicine.medical_specialty
Down-Regulation
Receptors
Cell Surface
reverse transcription polymerase chain reaction
Carcinoma
medicine
Humans
human
RNA
Messenger
Aged
Carcinoma
Transitional Cell
business.industry
Tumor Suppressor Proteins
Significant difference
Calcium-Binding Proteins
medicine.disease
major clinical study
human tissue
Urinary Bladder Neoplasms
gene expression
Neoplasm Grading
business
Popis: This study was undertaken to evaluate the expression of DMBT1 in bladder cancer and its correlation with clinico-pathological parameters analyzed in bladder carcinoma patients. We investigated DMBT1 in 56 paraffin embedded specimens of transitional cell carcinoma of the urinary bladder. We assessed DMBT1 gene expression at mRNA level by RT-PCR. Our results show 100% expression of DMBT1 in bladder carcinoma samples. Due to this preliminary results; gene expression was compared to tumor grade, and a significant difference was detected between grade 1 and 3 (p=0.028). The down-regulation of DMBT1 gene expression in carcinomas suggests the possible role in bladder cancer. © 2011 Informa UK, Ltd.
Databáze: OpenAIRE
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