Combined influence of illness duration and medication type on visual sensitivity in schizophrenia
| Autor: | Natanael Antonio dos Santos, Eveline Silva Holanda Lima, Thiago P. Fernandes, Natalia L. Almeida, Hemerson Fillipy Silva Sales |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Time Factors lcsh:RC435-571 Chlorpromazine medicine.medical_treatment media_common.quotation_subject contrast sensitivity function Visual impairment illness duration Vision Disorders Illness duration Visual processing Contrast Sensitivity 03 medical and health sciences Young Adult 0302 clinical medicine lcsh:Psychiatry medicine Contrast (vision) Humans Young adult Antipsychotic Vision Ocular media_common Psychiatric Status Rating Scales business.industry Case-control study Middle Aged medicine.disease psychiatry 030227 psychiatry Psychiatry and Mental health antipsychotics Treatment Outcome Schizophrenia Case-Control Studies Original Article Female medicine.symptom business 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | Brazilian Journal of Psychiatry, Issue: ahead, Published: 01 JUL 2019 Brazilian Journal of Psychiatry v.42 n.1 2020 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP Brazilian Journal of Psychiatry |
| Popis: | Objective: Patients with schizophrenia have visual processing impairments. The main findings from the literature indicate that these deficits may be related to differences in paradigms, medications, and illness duration. This study is part of a large-scale study investigating visual sensitivity in schizophrenia. Here we aimed to investigate the combined effects of illness duration and antipsychotic use on contrast sensitivity function. Methods: Data were collected from 50 healthy controls and 50 outpatients with schizophrenia (classified according to illness duration and medication type) aged 20-45 years old. The contrast sensitivity function was measured for spatial frequencies ranging from 0.2 to 20 cycles per degree using linear sine-wave gratings. Results: Patients with an illness duration > 5 years had more pronounced deficits. Differences in the combined effects of illness duration and antipsychotic use were marked in patients on typical antipsychotics who had been ill > 10 years. No significant differences were found between typical and atypical antipsychotics in patients with an illness duration < 5 years. Conclusion: Visual impairment was related to both long illness duration and medication type. These results should be tested in further studies to investigate pharmacological mechanisms. |
| Databáze: | OpenAIRE |
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