Polarographic Investigation of Dienogest
| Autor: | Sibel A. Ozkan, Melek Sirin Baymak, Hayati Celik, Bengi Uslu, Nurgul K. Bakirhan |
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| Přispěvatelé: | Hitit Üniversitesi, Fen Edebiyat Fakültesi, Kimya Bölümü |
| Rok vydání: | 2018 |
| Předmět: |
Polarography
Renewable Energy Sustainability and the Environment Chemistry [Belirlenecek] 010401 analytical chemistry 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Dienogest Materials Chemistry Electrochemistry 0210 nano-technology Nuclear chemistry |
| Zdroj: | Journal of The Electrochemical Society. 165:G128-G132 |
| ISSN: | 1945-7111 0013-4651 |
| DOI: | 10.1149/2.1211810jes |
| Popis: | Dienogest (DGN), is an orally administered synthetic progestin that has shown to have selective progesterone receptor (PR) agonistic activity and oral progestational potency on endometrium. In this paper, the investigation of electrochemical reduction of Dienogest on dropping mercury electrode (DME) is achieved and resulted in a reduction scheme that involves a two electron reduction of 3-keto-delta-4-group in the A-ring of the molecule. This observation is supported by comparison of the compound with model compounds of testosterone and norethisterone. In this study, electrochemical determination of the compound and its validation is also studied by differential pulse polarograhy (DPP). The results yielded good precision, accuracy and reproducibility. Calibration range was found as 2.00 × 10-6M to 1.00 × 10-4M, with LOD and LOQ values as 0.58 × 10-6M and 1.90 × 10-6M, respectively. © 2018 The Electrochemical Society. |
| Databáze: | OpenAIRE |
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