Hepatitis C Virus Transmission Clusters in Public Health and Correctional Settings, Wisconsin, USA, 2016–20171

Autor: Audrey F. Prieve, Ryan P. Westergaard, Ruth Koepke, Damien C. Tully, Karen A. Power, Karli R Hochstatter, Thomas Whyte, Todd M. Allen, David J. Bean, David W. Seal, Wajiha Z. Akhtar
Rok vydání: 2021
Předmět:
Microbiology (medical)
medicine.medical_specialty
Epidemiology
Hepatitis C virus
030231 tropical medicine
Hepacivirus
medicine.disease_cause
molecular epidemiology
Drug Users
03 medical and health sciences
Wisconsin
0302 clinical medicine
injection drug use
Environmental health
medicine
Humans
viruses
hepatitis
030212 general & internal medicine
Substance Abuse
Intravenous
Hepatitis C Virus Transmission Clusters in Public Health and Correctional Settings
Wisconsin
USA
2016–2017
Phylogeny
Retrospective Studies
Hepatitis
Wisconsin usa
Molecular epidemiology
business.industry
Transmission (medicine)
Research
Public health
global hepatitis outbreak surveillance technology
Outbreak
medicine.disease
Hepatitis C
United States
phylogenetics
Infectious Diseases
Prisons
transmission clusters
Female
Public Health
business
Zdroj: Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
Popis: Ending the hepatitis C virus (HCV) epidemic requires stopping transmission among networks of persons who inject drugs. Identifying transmission networks by using genomic epidemiology may inform community responses that can quickly interrupt transmission. We retrospectively identified HCV RNA-positive specimens corresponding to 459 persons in settings that use the state laboratory, including correctional facilities and syringe services programs, in Wisconsin, USA, during 2016-2017. We conducted next-generation sequencing of HCV and analyzed it for phylogenetic linkage by using the Centers for Disease Control and Prevention Global Hepatitis Outbreak Surveillance Technology platform. Analysis showed that 126 persons were linked across 42 clusters. Phylogenetic clustering was higher in rural communities and associated with female sex and younger age among rural residents. These data highlight that HCV transmission could be reduced by expanding molecular-based surveillance strategies to rural communities affected by the opioid crisis.
Databáze: OpenAIRE
Externí odkaz: