Hepatitis C Virus Transmission Clusters in Public Health and Correctional Settings, Wisconsin, USA, 2016–20171
Autor: | Audrey F. Prieve, Ryan P. Westergaard, Ruth Koepke, Damien C. Tully, Karen A. Power, Karli R Hochstatter, Thomas Whyte, Todd M. Allen, David J. Bean, David W. Seal, Wajiha Z. Akhtar |
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Rok vydání: | 2021 |
Předmět: |
Microbiology (medical)
medicine.medical_specialty Epidemiology Hepatitis C virus 030231 tropical medicine Hepacivirus medicine.disease_cause molecular epidemiology Drug Users 03 medical and health sciences Wisconsin 0302 clinical medicine injection drug use Environmental health medicine Humans viruses hepatitis 030212 general & internal medicine Substance Abuse Intravenous Hepatitis C Virus Transmission Clusters in Public Health and Correctional Settings Wisconsin USA 2016–2017 Phylogeny Retrospective Studies Hepatitis Wisconsin usa Molecular epidemiology business.industry Transmission (medicine) Research Public health global hepatitis outbreak surveillance technology Outbreak medicine.disease Hepatitis C United States phylogenetics Infectious Diseases Prisons transmission clusters Female Public Health business |
Zdroj: | Emerging Infectious Diseases |
ISSN: | 1080-6059 1080-6040 |
Popis: | Ending the hepatitis C virus (HCV) epidemic requires stopping transmission among networks of persons who inject drugs. Identifying transmission networks by using genomic epidemiology may inform community responses that can quickly interrupt transmission. We retrospectively identified HCV RNA-positive specimens corresponding to 459 persons in settings that use the state laboratory, including correctional facilities and syringe services programs, in Wisconsin, USA, during 2016-2017. We conducted next-generation sequencing of HCV and analyzed it for phylogenetic linkage by using the Centers for Disease Control and Prevention Global Hepatitis Outbreak Surveillance Technology platform. Analysis showed that 126 persons were linked across 42 clusters. Phylogenetic clustering was higher in rural communities and associated with female sex and younger age among rural residents. These data highlight that HCV transmission could be reduced by expanding molecular-based surveillance strategies to rural communities affected by the opioid crisis. |
Databáze: | OpenAIRE |
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