Donepezil eliminates suppressive effects of β-amyloid peptide (1-42) on long-term potentiation in the hippocampus
| Autor: | N. A. Kapai, V. G. Skrebitskii, E. I. Solntseva |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Long-Term Potentiation Hippocampus Peptide Pharmacology Hippocampal formation General Biochemistry Genetics and Molecular Biology Statistics Nonparametric Piperidines Alzheimer Disease mental disorders medicine Animals Donepezil Rats Wistar chemistry.chemical_classification Amyloid beta-Peptides Chemistry Long-term potentiation Population spike General Medicine medicine.disease Peptide Fragments Rats Neuroprotective Agents Indans Alzheimer's disease β amyloid peptide medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 149(1) |
| ISSN: | 1573-8221 |
| Popis: | β-Amyloid peptide 1-42 in a concentration of 200 nM impairs induction of long-term posttetanic potentiation of population spike in CA1 pyramidal neurons in rat hippocampal slices. Application of donepezil, a drug used for the treatment of Alzheimer disease, in a concentration of 1 μM eliminates the suppressive effect of β-amyloid peptide 1-42 on long-term posttenanic potentiation in the hippocampus. |
| Databáze: | OpenAIRE |
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