MiR-760 enhances TRAIL sensitivity in non-small cell lung cancer via targeting the protein FOXA1
| Autor: | Yu Liu, Xiang Zhang, Wei-Cong Huang, Lei Wang, Dezhi Cheng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hepatocyte Nuclear Factor 3-alpha Lung Neoplasms Down-Regulation Apoptosis Biology medicine.disease_cause TNF-Related Apoptosis-Inducing Ligand 03 medical and health sciences 0302 clinical medicine Carcinoma Non-Small-Cell Lung Cell Line Tumor microRNA medicine Gene silencing Humans Lung cancer Pharmacology Oncogene Base Sequence General Medicine medicine.disease respiratory tract diseases Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Proto-Oncogene Proteins c-bcl-2 030220 oncology & carcinogenesis Cancer research Ectopic expression FOXA1 Carcinogenesis |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 99 |
| ISSN: | 1950-6007 |
| Popis: | Non-small cell lung cancer (NSCLC) is one of the leading cause of death worldwide. TNF-related apoptosis-inducing ligand (TRAIL) is a promising anti-tumor agent with the ability to kill tumor cells while spare normal ones. MicroRNAs (miRNAs) are small, non-coding RNAs that play vital roles in carcinogenesis. Although miR-760 has been reported to be dysregulated in a variety of cancers, the role of miR-760 in NSCLC is not fully understood, and the relationship between miR-760 dysregulation and TRAIL sensitivity is still elusive. In the current study, we found that miR-760 is significantly downregulated in NSCLC tissues and cell lines. We also found that ectopic expression of miR-760, by targeting the FOXA1, enhanced TRAIL sensitivity in NSCLC cells. Correspondingly, silencing of FOXA1 also sensitized NSCLC cell to TRAIL-induced apoptosis and proliferation inhibition. In summary, these findings suggest that miR-760 should be considered as a tumor suppressor since it negatively regulates the oncogene protein FOXA1 and regulated TRAIL sensitivity in NSCLC cells. |
| Databáze: | OpenAIRE |
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