High-Density Lipoprotein Particle Size and Concentration and Coronary Risk
| Autor: | Kay-Tee Khaw, Karim El Harchaoui, Jean-Pierre Després, Benoit J. Arsenault, Nicholas J. Wareham, Erik S.G. Stroes, John J.P. Kastelein, Remco Franssen, G. Kees Hovingh, S. Matthijs Boekholdt, James D. Otvos |
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| Přispěvatelé: | Vascular Medicine, ACS - Amsterdam Cardiovascular Sciences, Cardiology |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Magnetic Resonance Spectroscopy Coronary Artery Disease chemistry.chemical_compound High-density lipoprotein Risk Factors Internal medicine Internal Medicine Humans Medicine Prospective Studies Particle Size Aged business.industry Cholesterol Cholesterol HDL nutritional and metabolic diseases General Medicine Middle Aged medicine.disease High-density lipoprotein particle Endocrinology chemistry Case-Control Studies Coronary risk Particle Female lipids (amino acids peptides and proteins) Particle size Metabolic syndrome business Lipoprotein |
| Zdroj: | Annals of internal medicine, 150(2), 84-U43. American College of Physicians |
| ISSN: | 0003-4819 |
| Popis: | Background: High-density lipoprotein (HDL) cholesterol levels are inversely related to risk for coronary artery disease (CAD). Because HDL particles are heterogeneous in size and composition, they may be differentially associated with other cardiovascular risk factors and with cardiovascular risk. Objective: To study the independent relationships of HDL size and particle concentration to risk for future CAD. Design: Nested case-control study within the EPIC (European Prospective Investigation into Cancer and Nutrition)-Norfolk cohort; baseline survey between 1993 and 1997, follow-up until November 2003. Setting: Norfolk, United Kingdom. Participants: Case patients were 822 apparently healthy men and women who developed CAD during follow-up. Control participants were 1401 participants who remained without CAD and were matched to case patients by sex, age, and enrollment time. Measurements: First CAD event leading to either hospitalization or death. Results: Nuclear magnetic resonance spectroscopy-measured HDL particle concentration (mean, 33.9 mu mol/L [SD, 5] vs. 32.9 mu mol/L [SD, 6]; P |
| Databáze: | OpenAIRE |
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