Influence of a High Salt Diet on Glomerular Injury and the Preventive Effects of Amiloride in Adriamycin Nephropathy
| Autor: | Masatoshi Fujishima, Akinori Nagashima, Seiya Okuda, Kiyoshi Tamaki |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Nephrology medicine.medical_specialty urologic and male genital diseases Muscle hypertrophy Amiloride Rats Sprague-Dawley Internal medicine medicine Animals Sodium Chloride Dietary Diuretics Glomerulosclerosis Focal Segmental urogenital system business.industry Sodium Glomerulosclerosis Glomerulonephritis Metabolism Glomerular Hypertrophy medicine.disease Rats Disease Models Animal Endocrinology Creatinine Toxicity business medicine.drug |
| Zdroj: | Nephron. 71:87-94 |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000188679 |
| Popis: | The effects of a high salt diet on glomerular hypertrophy and sclerosis were examined in a focal glomerular sclerosis rat model. Sprague-Dawley rats were injected twice with Adriamycin (ADR, 2.5 mg/kg body weight) and then divided into 3 groups: (1) ADR rats fed a 1% sodium chloride (NaCI) diet (control ADR rats); (2) ADR rats fed an 8% NaC1 diet (ADR-NaC1 group), and (3) ADR rats fed a 10% sodium bicarbonate (NaHCO3) diet (the ADR-NaHCO3 group), and were then observed for 8 weeks. There were no differences in the blood pressure levels between the control ADR and ADR-NaC1 groups. The urinary protein excretion was significantly less in the ADR-NaC1 and ADR-NaHCO3 groups than in the control ADR group. However, a progressive increase in the blood urea nitrogen and serum creatinine associated with extensive glomerular sclerosis and hypertrophy was only observed in the ADR-NaC1 group. An increase in the glomerular diameter preceded the development of glomerulosclerosis in this group. Furthermore, a daily administration of amiloride, a Na+/H+ exchanger inhibitor, to the ADR-NaC1 rats prevented the development of glomerular hypertrophy and sclerosis. These results therefore suggest that the aggravated effect of a high salt diet on glomerular sclerosis may be related to glomerular hypertrophy which is associated with the stimulation of the Na+/H+ exchanger. |
| Databáze: | OpenAIRE |
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