Detection of rotavirus before and after monovalent rotavirus vaccine introduction and vaccine effectiveness among children in mainland Tanzania
| Autor: | Inviollatha Chami, Veronica Msingwa, Happy Cholobi, Furaha Kyessi, Jason M. Mwenda, Innocent Michael, Antonia Materu, Kakuri Frank Omari, Tanzania Rotavirus Surveillance Teams, Jonathan Senyota, Asha Ussi Khamis, Hamisi Juma, Amina Mpamba, Anna Lyakurwa, Christopher Kamugisha, Alfred Chambo, Theresia Laswai, Umesh D. Parashar, Uforo Mariki, Yohana Fungo, Doreen Macha, Bhavin Jani, Faraja Lyamuya, Dafrossa Lyimo, Delphinius Mujuni, Juliana Dogani, Mark Waziri, Margaret M. Cortese, Elice C. Bendera, Josephine Mlay, Jackson Mchomvu, Deborah Tuju, Ronica Chard, Amina Mohamed Mshana, Adolfine Hokororo, Uyanjo Nkumbi, Nuswe Ambokile, Eugenia Stephen, Edward Mushi, Anivera Matojo, Mwanisha Seugendo, Dotto Kallovya, Esther Mchome, Angelina Saguti, Fausta Michael, Fatuma Lukwale |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Diarrhea
Rotavirus Acute diarrhea Pediatrics medicine.medical_specialty Rotavirus Antigen medicine.disease_cause Rate ratio Vaccines Attenuated Tanzania Rotavirus Infections 03 medical and health sciences Feces 0302 clinical medicine 030225 pediatrics medicine Humans 030212 general & internal medicine General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Rotavirus Vaccines Infant biology.organism_classification Vaccine introduction Rotavirus vaccine Gastroenteritis Infectious Diseases Child Preschool Molecular Medicine medicine.symptom business Sentinel Surveillance |
| Zdroj: | Vaccine. 36(47) |
| ISSN: | 1873-2518 |
| Popis: | BACKGROUND Monovalent rotavirus vaccine (RV1) was introduced in Tanzania in January 2013 under the Reach Every Child initiative, to be given at ages 6 and 10 weeks. We used the sentinel hospital rotavirus surveillance system to examine the rotavirus detection rate before and after vaccine introduction and estimate vaccine effectiveness. METHODS Before vaccine introduction, rotavirus surveillance was established at two mainland hospitals; children admitted for acute diarrhea were eligible for enrollment and stools were tested for rotavirus antigen. We compared the rotavirus positivity rate in the pre-vaccine period (Tanga Hospital, 2009 and 2011; Bugando Medical Centre, 2012) to that from post-introduction years, 2014-2015. In 2013, surveillance was established at 9 additional hospitals. We examined rotavirus positivity among infants at these sites for 2014-2015. We obtained vaccine records and calculated vaccine effectiveness at 3 sites using case-test-negative control design. RESULTS At Tanga Hospital, the rotavirus positivity rate among infants was 41% (102/251) pre-vaccine and 14% (28/197) in post-vaccine years (rate ratio: 0.35 [95% CI 0.22-0.54]). At Bugando, the positivity rate was 58% (83/143) pre-vaccine, and 18% (49/277) post-introduction (rate ratio 0.30 [95% CI 0.210.44]). Results were similar among children |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect