Oxygen tension level and human viral infections
| Autor: | Frédéric Morinet, Sylvie Pillet, Luana Casetti, Claude Capron, Jean-Hugues François |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Hepatitis
Chemotherapy medicine.medical_treatment Biology Hypoxia (medical) Oxygen tension level and viruses medicine.disease Antiviral Agents Oxygen tension Oxygen Hypoxia-Inducible Factor 1-Alpha Drug Therapy In vivo Virus Diseases Virology Immunology medicine Adjuvant therapy Humans Drug Therapy Combination Hypoxia inducible factor 1 alpha HIF-1 alpha inhibitor medicine.symptom Hypoxia Transcription factor |
| Zdroj: | Virology. 444(1-2):31-36 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2013.06.018 |
| Popis: | The role of oxygen tension level is a well-known phenomenon that has been studied in oncology and radiotherapy since about 60 years. Oxygen tension may inhibit or stimulate propagation of viruses in vitro as well as in vivo. In turn modulating oxygen metabolism may constitute a novel approach to treat viral infections as an adjuvant therapy. The major transcription factor which regulates oxygen tension level is hypoxia-inducible factor-1 alpha (HIF-1α). Down-regulating the expression of HIF-1α is a possible method in the treatment of chronic viral infection such as human immunodeficiency virus infection, chronic hepatitis B and C viral infections and Kaposi sarcoma in addition to classic chemotherapy. The aim of this review is to supply an updating concerning the influence of oxygen tension level in human viral infections and to evoke possible new therapeutic strategies regarding this environmental condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect