Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia (noni) fruit
| Autor: | C. Jarakae Jensen, Chen X. Su, Brett J. West |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Toxicology Rats Sprague-Dawley Toxicity Tests medicine Animals Humans Ingestion Morinda Noni juice Liver injury Hepatitis Phospholipidosis Traditional medicine medicine.diagnostic_test biology business.industry Hep G2 Cells medicine.disease biology.organism_classification Rats Subchronic toxicity Liver Female Liver function tests business |
| Zdroj: | The Journal of Toxicological Sciences. 34:581-585 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.34.581 |
| Popis: | Morinda citrifolia (noni) fruit juice has been approved as a safe food in many nations. A few cases of hepatitis in people who had been drinking noni juice have been reported, even though no causal link could be established between the liver injury and ingestion of the juice. To more fully evaluate the hepatotoxic potential of noni fruit juice, in vitro hepatotoxicity tests were conducted in human liver cells, HepG2 cell line. A subchronic oral toxicity test of noni fruit was also performed in Sprague-Dawley (SD) rats to provide benchmark data for understanding the safety of noni juice, without the potential confounding variables associated with many commercial noni juice products. Freeze-dried filtered noni fruit puree did not decrease HepG2 cell viability or induce neutral lipid accumulation and phospholipidosis. There were no histopathological changes or evidence of dose-responses in hematological and clinical chemistry measurements, including liver function tests. The no-observed-adverse-effect level (NOAEL) for freeze-dried noni fruit puree is greater than 6.86 g/kg body weight, equivalent to approximately 90 ml of noni fruit juice/kg. These findings corroborate previous conclusions that consumption of noni fruit juice is unlikely to induce adverse liver effects. |
| Databáze: | OpenAIRE |
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