The effect of a matrix metalloproteinase inhibitor on inflammation-mediated preterm delivery
| Autor: | Karen L. Koscica, Sandra E. Reznik, Jessica Placido, Cande V. Ananth |
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| Rok vydání: | 2006 |
| Předmět: |
Time Factors
Lipopolysaccharide Matrix metalloproteinase inhibitor Inflammation Pharmacology Matrix metalloproteinase Matrix Metalloproteinase Inhibitors chemistry.chemical_compound Mice Primary outcome Obstetric Labor Premature Pregnancy Medicine Animals Protease Inhibitors Preterm delivery business.industry Pregnancy Outcome Obstetrics and Gynecology Dipeptides medicine.disease Mice Inbred C57BL chemistry Anesthesia Models Animal Gestation Female medicine.symptom business Injections Intraperitoneal |
| Zdroj: | American journal of obstetrics and gynecology. 196(6) |
| ISSN: | 1097-6868 |
| Popis: | Objective Several matrix metalloproteinases (MMP) have been implicated in preterm parturition. We hypothesized that administration of a MMP inhibitor would reduce the rate of inflammation-mediated preterm delivery and prolong gestation in a mouse model. Study Design We utilized an animal model of endotoxin-induced preterm delivery using timed pregnant C57Bl6 mice. Test animals received lipopolysaccharide (LPS) followed by the MMP inhibitor at 1 dose 12 hours after the LPS. Control mice received the same dose of LPS, followed by a control solution 12 hours after the LPS. The primary outcome was preterm delivery rate. Results Mice in the study group had a significantly lower rate of preterm delivery (44%) compared to 100% in the controls ( P = .009). Furthermore, the latency between the administration of injection and delivery was also longer in the study group (means 28.3 hours, standard deviation 9.4 hours) than among controls (mean 15.7 hours, standard deviation 1.8 hours) ( P Conclusion Administration of an MMP inhibitor results in a decreased rate of inflammation-mediated preterm delivery in this animal model. |
| Databáze: | OpenAIRE |
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