Infection by Trypanosoma cruzi in the central nervous system in non-human mammals: a systematic review
| Autor: | Mariáurea Matias Sarandy, Mônica Morais-Santos, Reggiani Vilela Gonçalves, Rômulo Dias Novaes, Evaristo Villalba-Alemán |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chagas disease Trypanosoma cruzi 030231 tropical medicine Central nervous system Virulence Disease 03 medical and health sciences 0302 clinical medicine Genotype-phenotype distinction Genotype medicine Animals Chagas Disease Tropism Mammals biology medicine.disease biology.organism_classification 030104 developmental biology Infectious Diseases medicine.anatomical_structure Immunology Animal Science and Zoology Parasitology |
| Zdroj: | Parasitology. 146(8) |
| ISSN: | 1469-8161 |
| Popis: | Currently, the types and distribution of the lesions induced in the central nervous system (CNS) byTrypanosoma cruziremain unclear as the available evidence is based on fragmented data. Therefore, we developed a systematic review to analyse the main characteristics of the CNS lesions in non-human hosts infected. From a structured search on the PubMed/Medline and Scopus platforms, 32 studies were retrieved, subjected to data extraction and methodological bias analysis. Our results show that the most frequent alterations in the CNS are the presence of different forms ofT. cruziand intense lymphocytes infiltrates. The encephalon is the main target ofT. cruzi, and inflammatory changes in the CNS are more frequent and severe in the acute phase of infection. The parasite's genotype and phenotype are associated with the tropism and severity of the CNS lesions. The methodological limitations found in the studies were divergences in inoculation pathways, under-reporting of animal age and weight, sample calculation strategies and histopathological characterization. Since the changes were dependent on the pathogenicity and virulence of theT. cruzistrains, the genotype and phenotype characterization of the parasite are extremely relevant to predict changes in the CNS and the neurological manifestations associated with Chagas’ disease. |
| Databáze: | OpenAIRE |
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