Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis: a pilot study
| Autor: | Thomas Yssing Michaelsen, Hans Linde Nielsen, Ole Thorlacius-Ussing, Sabrina Just Kousgaard, Karina Frahm Kirk, Jakob Brandt, Mads Albertsen |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Denmark IBD Pilot Projects Intestinal dysbiosis Pouchitis Gastroenterology Faecal microbiota transplantation Chronic pouchitis Feces 03 medical and health sciences fluids and secretions 0302 clinical medicine Internal medicine microbiota medicine Humans Prospective Studies faecal microbiota transplantation Research evidence IPAA business.industry Remission Induction dysbiosis Fecal Microbiota Transplantation Middle Aged medicine.disease Gastrointestinal Microbiome 030220 oncology & carcinogenesis Chronic Disease Female 030211 gastroenterology & hepatology business Dysbiosis |
| Zdroj: | Kousgaard, S J, Michaelsen, T Y, Nielsen, H L, Kirk, K F, Brandt, J, Albertsen, M & Thorlacius-Ussing, O 2020, ' Clinical results and microbiota changes after faecal microbiota transplantation for chronic pouchitis : a pilot study ', Scandinavian Journal of Gastroenterology, vol. 55, no. 4, pp. 421-429 . https://doi.org/10.1080/00365521.2020.1748221 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Objectives: Research evidence suggests that chronic pouchitis is associated with intestinal dysbiosis. Faecal microbiota transplantation (FMT) has been proposed as a possible treatment. We performed a 6-month prospective, open-label, single-centre cohort pilot-study (NCT03538366) to investigate if FMT could improve clinical outcome and alter gut microbiota in patients with chronic pouchitis.Materials and methods: Nine adult patients with chronic pouchitis were included and allocated to 14 days FMT by enemas from five faecal donors, with a 6-month follow-up. Pouchitis severity was assessed using pouchitis disease activity index (PDAI) before and after FMT. Changes in gut microbiota, and engraftment of donor's microbiota were assessed in faecal samples.Results: All patients were treated with FMT for 14 continuous days. Overall, four of nine patients receiving FMT were in clinical remission at 30-day follow-up, and three patients remained in remission until 6-month follow-up. Clinical symptoms of pouchitis improved significantly between inclusion and 14-day follow-up (p = .02), but there was no improvement in PDAI between inclusion (mean 8.6) and 30-day follow-up (mean 5.2). Treatment with FMT caused a substantial shift in microbiota and increased microbial diversity in six patients, resembling that of the donors, with a high engraftment of specific donor microbiota.Conclusions: Symptomatic benefit in FMT treatment was found for four of nine patients with chronic pouchitis with increased microbial diversity and high engraftment of donor's microbiota. A larger, randomised controlled study is required to fully evaluate the potential role of FMT in treating chronic pouchitis. |
| Databáze: | OpenAIRE |
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