Antiparasitic, nematicidal and antifouling constituents fromJuniperusberries
| Autor: | Babu L. Tekwani, Jan Pieter Hendrik Bosselaers, Shabana I. Khan, Md. Abdul Gafur, Jaber S. Mossa, Farouk S. El-Feraly, Volodymyr Samoylenko, D. Chuck Dunbar, Ilias Muhammad, Samir A. Ross |
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| Rok vydání: | 2008 |
| Předmět: |
Totarol
Plasmodium falciparum Antiprotozoal Agents Microbial Sensitivity Tests Juniperus procera Gas Chromatography-Mass Spectrometry Cedrol Labdane chemistry.chemical_compound Botany Animals Caenorhabditis elegans Abietane Pharmacology biology Traditional medicine Antinematodal Agents biology.organism_classification Terpenoid Anti-Bacterial Agents Ferruginol chemistry Fruit Juniperus Abietanes Artemia Diterpenes Artemia salina Resins Plant Leishmania donovani |
| Zdroj: | Phytotherapy Research. 22:1570-1576 |
| ISSN: | 1099-1573 0951-418X |
| DOI: | 10.1002/ptr.2460 |
| Popis: | A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC(50) = 1.9 and 2.0 microg/mL, respectively), while totarol (6), ferruginol (7) and 7beta-hydroxyabieta-8,13-diene-11,12-dione (8) inhibited Leishmania donovani promastigotes with IC(50) values of 3.5-4.6 microg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 microg/mL and 1 microg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E-communic acid (4) and 4-epi-abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9). Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea. |
| Databáze: | OpenAIRE |
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