The cellular and molecular regulation of 1,25(OH)2D3 production
| Autor: | Chhanda Dutta, Gail S. Marchetto, Raymond D. Blanchard, Chilung Tang, Shu-Yin Chou, Helen L. Henry, Robert Penny, Noreen S. Cunningham |
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| Rok vydání: | 1992 |
| Předmět: |
Cell type
Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Parathyroid hormone Biology Models Biological Biochemistry chemistry.chemical_compound Endocrinology Calcitriol Biosynthesis medicine Animals Homeostasis Humans Protein kinase A Molecular Biology Protein Kinase C Calcifediol 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Calcium metabolism Cell Biology Steroid hormone chemistry Parathyroid Hormone Molecular Medicine Intracellular |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 41:401-407 |
| ISSN: | 0960-0760 |
| DOI: | 10.1016/0960-0760(92)90365-p |
| Popis: | The synthesis of 1,25(OH)2D3 is a critical control point in the regulation of calcium metabolism, and possibly in the growth and differentiation of a number of cell types. This paper reviews our current understanding of the regulation of this process at the cellular and molecular levels, with the emphasis on the mechanisms of feedback control 1,25(OH)2D3 itself, control of parathyroid hormone, the roles of cyclic AMP dependent protein kinase and protein kinase C, and the interaction between the various intracellular regulators of 1,25(OH)2D3 production. |
| Databáze: | OpenAIRE |
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