Alterations in gray matter volumes and intrinsic activity in the prefrontal cortex are associated with suicide attempts in patients with bipolar disorder
| Autor: | Feng Wu, Fay Y. Womer, Lifei Wang, Yanqing Tang, Elliot Kale Edmiston, Shengnan Wei, Lingtao Kong, Yimeng Zhao, Yifang Zhou, Fei Wang, Xiaowei Jiang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Bipolar Disorder Intrinsic activity Neuroscience (miscellaneous) Prefrontal Cortex Suicide Attempted computer.software_genre 03 medical and health sciences 0302 clinical medicine Neuroimaging Voxel Internal medicine Healthy control medicine Humans Radiology Nuclear Medicine and imaging In patient Bipolar disorder Gray Matter Prefrontal cortex business.industry Amplitude of low frequency fluctuations medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health nervous system Cardiology business computer 030217 neurology & neurosurgery |
| Zdroj: | Psychiatry research. Neuroimaging. 307 |
| ISSN: | 1872-7506 |
| Popis: | Bipolar disorder (BD) is associated with increased suicidal behavior. Understanding the neural features of suicide attempts (SA) in patients with BD is critical to preventing suicidal behavior. The prefrontal cortex (PFC) is a key region related to SA. In this study, forty BD patients with a history of SA (BD+SA), 70 BD patients without a history of SA (BD-SA), and 110 individuals in a healthy control (HC) group underwent structural magnetic resonance imaging (MRI) and resting-state functional MRI. We used voxel-based morphometry (VBM) and amplitude of low frequency fluctuations (ALFF) techniques to examine the gray matter volumes (GMVs) and ALFF values in the PFC. Compared with the HC group, both the BD+SA and BD-SA groups had lower GMVs and higher ALFF values in the medial PFC (MPFC), ventral PFC (VPFC), and dorsolateral PFC (DLPFC). The ALFF values in the MPFC, VPFC, and DLPFC in the BD+SA group were significantly higher than those in the BD-SA group. These findings suggest that BD patients with SA have intrinsic activity abnormalities in PFC regions. This provides potentially identifiable neuroimaging markers in BD patients with SA that could be used to increase our understanding of suicidal behavior. |
| Databáze: | OpenAIRE |
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