The uptake by blood-borne phagocytes of monosodium urate is dependent on heat-labile serum factor(s) and divalent cations

Autor:	Christina Janko, Luis E. Muñoz, Moritz Strysio, Martin Herrmann, Christine Schorn, Georg Schett
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Phagocytes Gout Chemistry Cations Divalent Immunology Inflammation Endogeny Heat labile medicine.disease Microbiology Divalent Uric Acid Monosodium urate medicine Immunology and Allergy Cytokines Humans Lupus Erythematosus Systemic Tumor necrosis factor alpha In patient medicine.symptom
Zdroj:	Autoimmunity. 43(3)
ISSN:	1607-842X
Popis:	Accumulation in tissues of post-apoptotic cells is a feature frequently observed in patients with systemic lupus erythematosus and in murine models of systemic autoimmune diseases. One of the endogenous danger molecules released by secondarily necrotic cells is monosodium urate (MSU), which is already established to be the causative agent of gout. Here, we show that MSU is taken up by eosinophils, neutrophils and monocytes in a process involving (a) heat-labile serum factor(s) and divalent cations. The uptake induces the release of the pro-inflammatory cytokines IL-1beta/IL-18/TNFalpha and IL-6/IL-8 by monocytes and PMN, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e842c82378ef185a22e01e841df7938c https://pubmed.ncbi.nlm.nih.gov/20187703 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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