Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome
| Autor: | Jun Tayama, Sayaka Ogawa, Susumu Shirabe, Atsushi Takeoka, Masaki Hayashida, Hironori Yamasaki, Masakazu Kobayashi, Tatsuo Saigo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Bacterial Diseases
Male Atrophic gastritis Physiology lcsh:Medicine Pathology and Laboratory Medicine Gastroenterology Biochemistry Immunoglobulin G Habits 0302 clinical medicine Risk Factors Helicobacter Immune Physiology Pepsinogen A Medicine and Health Sciences Smoking Habits Odds Ratio Pepsinogen C Medicine Gastrointestinal Infections Public and Occupational Health lcsh:Science Immune Response Metabolic Syndrome Multidisciplinary Immune System Proteins biology Middle Aged Antibodies Bacterial Bacterial Pathogens Infectious Diseases Medical Microbiology 030220 oncology & carcinogenesis Gastritis 030211 gastroenterology & hepatology Female medicine.symptom Pathogens Research Article Adult Gastritis Atrophic medicine.medical_specialty Immunology Gastroenterology and Hepatology Microbiology Antibodies 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Internal medicine Confidence Intervals Humans Risk factor Microbial Pathogens Inflammation Behavior Bacteria Helicobacter pylori business.industry lcsh:R Organisms Biology and Life Sciences Proteins Odds ratio Physical Activity medicine.disease biology.organism_classification Confidence interval Helicobacter Pylori Infection biology.protein lcsh:Q Metabolic syndrome business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 11, p e0166588 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Background Helicobacter pylori (HP) infection is implicated in gastric and extra-gastric diseases. While gastritis-related chronic inflammation represents a known trigger of metabolic disturbances, whether metabolic syndrome (MetS) is affected by gastritis status remains unclear. We aimed to clarify the effect of HP-related gastritis on the risk of MetS. Materials and Methods We retrospectively enrolled patients undergoing screening for MetS between 2014 and 2015. Investigations included HP-specific immunoglobulin G (IgG) antibody assays to detect HP infection, and serum pepsinogen assays to evaluate atrophic gastritis status. The risk of MetS was evaluated via multiple logistic regression analyses with two covariates: serum HP infection status (IgG levels) and atrophic gastritis status (two criteria were applied; pepsinogen I/II ratio < 3 or both pepsinogen I levels ≤ 70 μg/L and pepsinogen I/II ratio < 3). Results Of 1,044 participants, 247 (23.7%) were HP seropositive, and 62 (6.0%) had MetS. HP seronegative and seropositive patients had similar risks of MetS. On the other hand, AG (defined in terms of serum PG I/II |
| Databáze: | OpenAIRE |
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