Extent of ischemic stimulus and plasma beta-endorphin levels in silent myocardial ischemia
| Autor: | Hiroyuki Hikita, Hirokuni Etsuda, Akira Kurita, Haruo Nakamura, Bonpei Takase, Kimio Satomura |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Ischemia Myocardial Ischemia Coronary Disease Stimulus (physiology) Asymptomatic Coronary artery disease Angioplasty Internal medicine medicine Humans Angioplasty Balloon Coronary Silent myocardial ischemia Aged Vascular disease business.industry beta-Endorphin Middle Aged medicine.disease Prognosis Cardiology Exercise Test Population study Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | American heart journal. 135(5 Pt 1) |
| ISSN: | 0002-8703 |
| Popis: | Background β-Endorphin has been reported to play a role in the mechanism of silent myocardial ischemia. Objectives Plasma β-endorphin levels during coronary angioplasty–induced silent and symptomatic myocardial ischemia were compared with those during exercise-induced silent ischemia. Methods and Results The study population consisted of 40 nondiabetic patients with angioplasty-indicated coronary artery disease. All patients underwent exercise treadmill testing 2 to 4 days before angioplasty. Patients were divided into three groups: group 1, 10 patients with silent ischemia during exercise and angioplasty; group 2, 15 patients with silent ischemia during exercise and symptomatic ischemia during angioplasty; and group 3, 15 patients with symptomatic ischemia during both exercise and angioplasty. In group 1, plasma β-endorphin levels during balloon inflation were significantly higher than in groups 2 and 3 and also significantly higher than during exercise. In group 2, plasma β-endorphin levels were significantly elevated at exercise-induced silent myocardial ischemia and balloon-induced symptomatic myocardial ischemia, but the levels between exercise and balloon inflation were not significantly different. Conclusions For "silent" myocardial ischemia, it may be necessary for β-endorphin levels to increase to sufficiently high levels to suppress anginal symptoms in response to the degree of ischemic stimuli. (Am Heart J 1998;135:813-8.) |
| Databáze: | OpenAIRE |
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