Con-Struct Map: a comparative contact map analysis tool
| Autor: | Philip E. Bourne, Eric D. Scheeff, Jo-Lan Chung, John E. Beaver |
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| Rok vydání: | 2007 |
| Předmět: |
Models
Molecular Statistics and Probability Molecular Sequence Data Structural alignment Computational biology Biology Bioinformatics Biochemistry User-Computer Interface Protein structure Multiple structure alignment Sequence Analysis Protein Protein Interaction Mapping Computer Graphics Computer Simulation Amino Acid Sequence Molecular Biology Supplementary data Binding Sites Proteins Computer Science Applications Computational Mathematics Models Chemical Computational Theory and Mathematics struct Sequence Alignment Algorithms Software Protein Binding |
| Zdroj: | Bioinformatics. 23:2491-2492 |
| ISSN: | 1367-4811 1367-4803 |
| DOI: | 10.1093/bioinformatics/btm356 |
| Popis: | Summary: Con-Struct Map is a graphical tool for the comparative study of protein structures. The tool detects potential conserved residue contacts shared by multiple protein structures by superimposing their contact maps according to a multiple structure alignment. In general, Con-Struct Map allows the study of structural changes resulting from, e.g. sequence substitutions, or alternatively, the study of conserved components of a structure framework across structurally aligned proteins. Specific applications include the study of sequence-structure relationship in distantly related proteins and the comparisons of wild type and mutant proteins.Availability: http://pdbrs3.sdsc.edu/ConStructMap/viewer_argument_generator/singleArgumentsContact: bourne@sdsc.eduSupplementary information: Supplementary data are available at Bioinformatics online. |
| Databáze: | OpenAIRE |
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