Feeding of the water extract from Ganoderma lingzhi to rats modulates secondary bile acids, intestinal microflora, mucins, and propionate important to colon cancer
Autor: | Yukako Okazaki, Norihisa Kato, Thanutchaporn Kumrungsee, Yongshou Yang, Hiroyuki Tomotake, Dwi Eva Nirmagustina |
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Rok vydání: | 2017 |
Předmět: |
Male
0301 basic medicine Lithocholic acid Ganoderma Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Microbiology Bile Acids and Salts Rats Sprague-Dawley Eating Feces 03 medical and health sciences chemistry.chemical_compound Cecum medicine Animals Molecular Biology Carcinogen chemistry.chemical_classification biology Body Weight Organic Chemistry Deoxycholic acid Mucin Mucins Clostridium leptum Water General Medicine Fatty Acids Volatile biology.organism_classification Diet Gastrointestinal Microbiome Immunoglobulin A Rats 030104 developmental biology medicine.anatomical_structure chemistry Colonic Neoplasms Propionate Propionates Biotechnology |
Zdroj: | Bioscience, Biotechnology, and Biochemistry. 81:1796-1804 |
ISSN: | 1347-6947 0916-8451 |
DOI: | 10.1080/09168451.2017.1343117 |
Popis: | Consumption of reishi mushroom has been reported to prevent colon carcinogenesis in rodents, although the underlying mechanisms remain unclear. To investigate this effect, rats were fed a high-fat diet supplemented with 5% water extract from either the reishi mushroom (Ganoderma lingzhi) (WGL) or the auto-digested reishi G. lingzhi (AWGL) for three weeks. Both extracts markedly reduced fecal secondary bile acids, such as lithocholic acid and deoxycholic acid (colon carcinogens). These extracts reduced the numbers of Clostridium coccoides and Clostridium leptum (secondary bile acids-producing bacteria) in a per g of cecal digesta. Fecal mucins and cecal propionate were significantly elevated by both extracts, and fecal IgA was significantly elevated by WGL, but not by AWGL. These results suggest that the reishi extracts have an impact on colon luminal health by modulating secondary bile acids, microflora, mucins, and propionate that related to colon cancer. |
Databáze: | OpenAIRE |
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