Neuro-oncology family caregivers are at risk for systemic inflammation
| Autor: | Anna L. Marsland, Jason Weimer, Barbara A. Given, Dianxu Ren, Richard Schulz, Catherine M. Bender, Paula R. Sherwood, Thomas J. Price, Heidi S. Donovan, Jennifer Prince, Florien W. Boele, Charles W. Given |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Time Factors Neurology Neuro oncology Anxiety Logistic regression Systemic inflammation Article Proinflammatory cytokine 03 medical and health sciences Sex Factors 0302 clinical medicine Cost of Illness Risk Factors Neoplasms medicine Humans Longitudinal Studies Obesity Psychiatry Inflammation Depression Interleukin-6 Family caregivers business.industry Age Factors Caregiver burden Middle Aged Self Concept Interleukin 1 Receptor Antagonist Protein Caregivers Oncology 030220 oncology & carcinogenesis Female Neurology (clinical) medicine.symptom business Biomarkers Stress Psychological 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Neuro-Oncology. 128:109-118 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-016-2083-3 |
| Popis: | Prolonged periods of family caregiving can induce stress levels that may negatively influence caregiver health. However, the physiologic effect of psychological distress in oncology family caregivers has received little attention. Therefore we aimed to determine longitudinal profiles of inflammatory cytokines (IL-6 and IL-1ra) in neuro-oncology caregivers and identify associations between psychological distress and cytokine levels. Depressive symptoms, anxiety, caregiver burden and blood were collected from 108 adult caregivers at adult patients' diagnosis, 4-, 8-, and 12-months. Trajectory analyses of log transformed cytokine levels were performed. Multiple logistic regression analyses evaluated the impact of psychological distress on cytokine levels. For both cytokines, two distinct populations were identified, neither of which changed over time. High IL-1ra was associated with male caregivers with anxiety (OR = 1.7; 95 %CI 1.06-2.83) and obese caregivers (BMI = 40) who felt burdened due to disrupted schedules (OR = 1.3; 95 %CI 1.02-1.77). Conversely, caregivers with a healthy weight (BMI = 25) who felt burdened due to disrupted schedules were less likely to have high IL-1ra (OR = 0.71; 95 %CI 0.54-0.92). Caregivers ≤30 years old with lower self-esteem from caregiving were 1.16 times (95 %CI 1.04-1.30) more likely to have high IL-6. Analysis demonstrated groups of family caregivers with high and low levels of systemic inflammation and these levels did not change longitudinally over the care trajectory. Poor physical health in family caregivers may have a negative impact on the burden placed on the healthcare system in general and on the well-being of neuro-oncology patients in particular. |
| Databáze: | OpenAIRE |
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