Intermittent Nitrate Therapy for Prior Myocardial Infarction Does Not Induce Rebound Angina nor Reduce Cardiac Events
| Autor: | Kinji ISHIKAWA, Tadahiko YAMAMOTO, Ken KANAMASA, Takahiro HAYASHI, Toshihiko TAKENAKA, Akio KIMURA, Masaru MIYATAKA, Hiroshi YABUSHITA, Koji KITAYAMA, null on Behalf of the Secondary Prevention Group |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Administration Oral Coronary Vasospasm Isosorbide Dinitrate Administration Cutaneous Disease-Free Survival Drug Administration Schedule Angina Pectoris law.invention Angina Nitroglycerin Randomized controlled trial Recurrence law Internal medicine Internal Medicine medicine Humans Myocardial infarction Aged Retrospective Studies Heart Failure Exercise Tolerance business.industry Cardiovascular Agents Vasospasm Retrospective cohort study Drug Tolerance General Medicine Odds ratio Middle Aged medicine.disease Regimen Treatment Outcome Delayed-Action Preparations Coronary vasospasm Cardiology Drug Therapy Combination Female business Follow-Up Studies |
| Zdroj: | Internal Medicine. 39:1020-1026 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.39.1020 |
| Popis: | Objective Long-term nitrate therapy for ischemic heart disease may cause drug tolerance which diminishes its beneficial effects; consequently, intermittent administration of nitrates is recommended. With this regimen, however, the potential occurrence of rebound angina during the nitrate-free intervals is a source of concern. Subjects and Methods We carried out a retrospective study of 606 patients to determine whether rebound angina occurred when conventional continuous nitrate administration was replaced by intermittent administration as part of a long-term therapy protocol for prior myocardial infarction. The subjects were receiving treatment for myocardial infarction and included 293 patients treated with nitrates (Nitrate group) and 313 patients who were not (Nonitrate group). The former included 186 patients who received intermittent nitrate administration (Intermittent group) and 107 patients who received continuous administration (Continuous group). The mean period of observation was 4.3±1.6 months. Results There were no cases of rebound angina in the Intermittent group. Cardiac events occurred in one case in the No-nitrate group (0.3%), in 4 cases in the Continuous group (3.7%) and in 2 cases in the Intermittent group (1.1%). The incidence of cardiac events was thus significantly increased in the Continuous group compared to the No-nitrate group (p |
| Databáze: | OpenAIRE |
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