Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment
| Autor: | Keisuke Fujitaka, Masayoshi Iwasaki, Dipak K. Das, Emiko Nomura, Fusakazu Jo, Mitsushige Nishikawa, Hajime Otani, Toshiji Iwasaka, Hiromi Jo |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Endocrinology Diabetes and Metabolism Drug Compounding Vasodilator Agents Hyperlipidemias Gastroenterology Endocrinology Insulin resistance Internal medicine Diabetes mellitus Stilbenes medicine Diabetes Mellitus Humans Endothelial dysfunction Life Style Aged Metabolic Syndrome Nutrition and Dietetics medicine.diagnostic_test business.industry Standard treatment Middle Aged medicine.disease Vasodilation medicine.anatomical_structure Resveratrol Hypertension Female Endothelium Vascular Metabolic syndrome Insulin Resistance business Lipid profile Dyslipidemia |
| Zdroj: | Nutrition research (New York, N.Y.). 31(11) |
| ISSN: | 1879-0739 |
| Popis: | Resveratrol is known to improve endothelial function in animals, but little is known about its effect on human subjects. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors underlying endothelial dysfunction. We hypothesized that the modified resveratrol, Longevinex, improves endothelial function in patients with MetS. Thirty-four patients who had been treated for MetS and lifestyle-related disease were randomly assigned to group A, in which Longevinex was administered for 3 months and then discontinued for 3 months, whereas in the time-matched group B, Longevinex was administered between 3 and 6 months. These 2 groups of patients received similar drugs at baseline for diabetes mellitus, dyslipidemia, or hypertension. Flow-mediated dilatation significantly increased during the administration of Longevinex but decreased to baseline 3 months after the discontinuation of Longevinex in the group A patients. Conversely, in the group B patients, flow-mediated dilatation remained unchanged for the first 3 months without Longevinex but was significantly increased 3 months after the treatment with Longevinex. Longevinex did not significantly affect blood pressure, insulin resistance, the lipid profile or inflammatory markers during 6-month follow-up. These results demonstrate that Longevinex specifically improves endothelial function in subjects with MetS who were receiving standard therapy for lifestyle-related disease. |
| Databáze: | OpenAIRE |
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