Extracellular matrix composition in COPD
Autor: | S. Fernezlian, Thais Mauad, Luiz Fernando Ferraz da Silva, Salvatore Battaglia, Tatiana Lanças, Pieter S. Hiemstra, Peter J. Sterk, Marisa Dolhnikoff, Klaus F. Rabe, Peter J. Roughley, Raquel Annoni, Andreina Bruno, Ryan Yukimatsu Tanigawa, Marcus Matsushita |
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Přispěvatelé: | Annoni, R, Lancas, T, Yukimatsu Tanigawa, R, de Medeiros Matsushita, M, de Morais Fernezlian, S, Bruno, A, Fernando Ferraz da Silva, L, Roughley, PJ, Battaglia, S, Dolhnikoff, M, Hiemstra, PS, Sterk, PJ, Rabe, KF, Mauad, T, Amsterdam institute for Infection and Immunity, Pulmonology |
Jazyk: | angličtina |
Rok vydání: | 2012 |
Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Lumican Pathology medicine.medical_specialty Decorin Tenascin Settore MED/10 - Malattie Dell'Apparato Respiratorio Pulmonary Disease Chronic Obstructive Biglycan Parenchyma medicine Humans COPD Lung Aged biology business.industry Smoking Middle Aged respiratory system medicine.disease Immunohistochemistry Extracellular Matrix Fibronectins Respiratory Function Tests respiratory tract diseases medicine.anatomical_structure Chondroitin Sulfate Proteoglycans Keratan Sulfate Case-Control Studies biology.protein Versican Female Collagen business |
Zdroj: | European respiratory journal, 40(6), 1362-1373. European Respiratory Society |
ISSN: | 0903-1936 |
Popis: | Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung composition of chronic obstructive pulmonary disease (COPD) patients differs from that observed in smoking and nonsmoking subjects without airflow obstruction. We determined the fractional areas of elastic fibres, type-I, -III and -IV collagen, versican, decorin, biglycan, lumican, fibronectin and tenascin in different compartments of the large and small airways and lung parenchyma in 26 COPD patients, 26 smokers without COPD and 16 nonsmoking control subjects. The fractional area of elastic fibres was higher in non-obstructed smokers than in COPD and nonsmoking controls, in all lung compartments. Type-I collagen fractional area was lower in the large and small airways of COPD patients and in the small airways of non-obstructed smokers than in nonsmokers. Compared with nonsmokers, COPD patients had lower versican fractional area in the parenchyma, higher fibronectin fractional area in small airways and higher tenascin fractional area in large and small airways compartments. In COPD patients, significant correlations were found between elastic fibres and fibronectin and lung function parameters. Alterations of the major ECM components are widespread in all lung compartments of patients with COPD and may contribute to persistent airflow obstruction. |
Databáze: | OpenAIRE |
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