Hepatitis C genotype 1 mosaic vaccines are immunogenic in mice and induce stronger T-cell responses than natural strains

Autor:	Dan H. Barouch, Joseph Marcotrigiano, Rebecca Dilan, Will Fischer, James Theiler, Elena E. Giorgi, Erica N. Borducchi, Karina Yusim, Bette T. Korber, Kelly Stanley
Rok vydání:	2012
Předmět:	Microbiology (medical) Viral Hepatitis Vaccines Hepatitis C virus Hepacivirus T cell viruses T-Lymphocytes Clinical Biochemistry Immunology Mosaic protein Viral Nonstructural Proteins medicine.disease_cause Antibodies Viral Mice Hcv genotype 1 Viral Envelope Proteins Genotype medicine Immunology and Allergy Animals Mice Inbred BALB C Vaccines Synthetic Vaccines biology Vaccination virus diseases Hepatitis C biology.organism_classification medicine.disease Virology digestive system diseases medicine.anatomical_structure
Zdroj:	Clinical and vaccine immunology : CVI. 20(2)
ISSN:	1556-679X
Popis:	Despite improved hepatitis C virus (HCV) treatments, vaccines remain an effective and economic option for curtailing the epidemic. Mosaic protein HCV genotype 1 vaccine candidates designed to address HCV diversity were immunogenic in mice. They elicited stronger T-cell responses to NS3-NS4a and E1-E2 proteins than did natural strains, as assessed with vaccine-matched peptides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e831b537d8a55d07914a363a2e3e2638 https://pubmed.ncbi.nlm.nih.gov/23221002 Zobrazit plný text záznamu