Bone-forming perivascular cells: Cellular heterogeneity and use for tissue repair
| Autor: | Jiajia Xu, Stefano Negri, Yiyun Wang, Winters R. Hardy, Ginny Ching Yun Hsu, Lijun Ding, Aaron W. James, Bruno Péault, Mario Gomez-Salazar, Zhao Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gene isoform
ALDH Biology LAMP1 Article adipogenesis osteogenesis CD107a Antigen In vivo perivascular stem cell Animals Progenitor cell mesenchymal stem cell Mammals Wound Healing Tissue Engineering tunica adventitia Tunica Adventitia Mesenchymal stem cell adipose stem cell Cell Differentiation Mesenchymal Stem Cells Cell Biology Cell biology Adipogenesis mesenchymal stromal cell Molecular Medicine CD10 Pericytes exocytosis Developmental Biology CD140a |
| Zdroj: | Stem Cells |
| Popis: | Mesenchymal progenitor cells are broadly distributed across perivascular niches—an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tunica adventitia, the outer layer of blood vessel walls populated by cells with a fibroblastic morphology. The diversity and functions of (re)generative cells present in this outermost perivascular niche are under intense investigation; we have reviewed herein our current knowledge of adventitial cell potential with a somewhat narrow focus on bone formation. Antigens of interest to functionally segregate adventicytes are discussed, including CD10, CD107a, aldehyde dehydrogenase isoforms, and CD140a, among others. Purified adventicytes (such as CD10+, CD107alow, and CD140a+ cells) have stronger osteogenic potential and promote bone formation in vivo. Recent bone tissue engineering applications of adventitial cells are also presented. A better understanding of perivascular progenitor cell subsets may represent a beneficial advance for future efforts in tissue repair and bioengineering. |
| Databáze: | OpenAIRE |
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