Spatial Working Memory in Humans Depends on Theta and High Gamma Synchronization in the Prefrontal Cortex
| Autor: | Andrea Antal, Zsolt Turi, Gabriel Amador de Lara, Walter Paulus, Ivan Alekseichuk |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_treatment Prefrontal Cortex Electroencephalography Biology Transcranial Direct Current Stimulation Spatial memory General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Young Adult 0302 clinical medicine Rhythm medicine Humans Cortical Synchronization Prefrontal cortex Transcranial alternating current stimulation Spatial Memory Quantitative Biology::Neurons and Cognition medicine.diagnostic_test Transcranial direct-current stimulation Working memory 030104 developmental biology Memory Short-Term Female General Agricultural and Biological Sciences Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Current biology : CB. 26(12) |
| ISSN: | 1879-0445 |
| Popis: | Previous, albeit correlative, findings have shown that the neural mechanisms underlying working memory critically require cross-structural and cross-frequency coupling mechanisms between theta and gamma neural oscillations. However, the direct causality between cross-frequency coupling and working memory performance remains to be demonstrated. Here we externally modulated the interaction of theta and gamma rhythms in the prefrontal cortex using novel cross-frequency protocols of transcranial alternating current stimulation to affect spatial working memory performance in humans. Enhancement of working memory performance and increase of global neocortical connectivity were observed when bursts of high gamma oscillations (80-100 Hz) coincided with the peaks of the theta waves, whereas superimposition on the trough of the theta wave and low gamma frequency protocols were ineffective. Thus, our results demonstrate the sensitivity of working memory performance and global neocortical connectivity to the phase and rhythm of the externally driven theta-gamma cross-frequency synchronization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|