| Autor: |
Eduardo Marques-García, Samuel Torres-Landa, Rodrigo Barquera, Joaquín Zúñiga, Diana Iraíz Hernández-Zaragoza, Blanca A. Blancas Breña, Enrique Coss-Adame, Gustavo Ramírez, Axel A. Hernández-Ávila, Nora E. Regino, Axel Palacios-Ramírez, Edgar Alejandro-Medrano, Alfredo Cruz-Lagunas, Luis Jiménez-Alvarez, Edmond J. Yunis, Ramón Espinosa-Soto, Fernanda Romero-Hernández, Miguel A. Valdovinos, Julio Granados, Janette Furuzawa-Carballeda, Gonzalo Torres-Villalobos, Daniel Azamar-Llamas |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
PLoS ONE
PLoS One
PLoS ONE, Vol 13, Iss 8, p e0201676 (2018) |
| ISSN: |
1932-6203 |
| Popis: |
Idiopathic achalasia is a relatively infrequent esophageal motor disorder for which major histocompatibility complex (MHC) genes are well-identified risk factors. However, no information about HLA-achalasia susceptibility in Mexicans has previously been reported. We studied a group of 91 patients diagnosed with achalasia and 234 healthy controls with Mexican admixed ancestry. HLA alleles and conserved extended haplotypes were analyzed using high-resolution HLA typing based on Sanger and next-generation sequencing technologies. Admixture estimates were determined using HLA-B and short tandem repeats. Results were analyzed by non-parametric statistical analysis and Bonferroni correction. P-values < 0.05 were considered significant. Patients with achalasia had 56.7% Native American genes, 24.7% European genes, 16.5% African genes and 2.0% Asian genes, which was comparable with the estimates in the controls. Significant increases in the frequencies of alleles DRB1*14:54 and DQB1*05:03 and the extended haplotypes DRB1*14:54-DQB1*05:03 and DRB1*11:01-DQB1*03:01, even after Bonferroni correction (pC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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