Individualized neuropathic pain therapy based on phenotyping: are we there yet?
| Autor: | Jan Carl Otto, Julia Forstenpointner, Ralf Baron |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Predictive validity
Pain Threshold medicine.medical_specialty Treatment response Sensation Signs and symptoms Sensory system Pharmacological treatment 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology medicine Humans Precision Medicine Intensive care medicine Prospective cohort study business.industry Precision medicine Anesthesiology and Pain Medicine Phenotype Neurology Neuropathic pain Neuralgia Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Pain. 159(3) |
| ISSN: | 1872-6623 |
| Popis: | Patients with the same neuropathic pain disorder may have completely different sensory signs and symptoms yet receive the same medicinal treatment. New concepts suggest that patient stratification according to their pain mechanisms, reflected in their sensory phenotype, could be promising to implement an individualized therapy in neuropathic pain. Retrospective classification of patients according to their sensory phenotype showed predictive validity and reliability for treatment response in certain subgroups of patients. Recent prospective studies using stratification based on sensory phenotypes confirm this concept. In this article, we review the recent accomplishments towards an individualized pharmacological treatment of neuropathic pain. |
| Databáze: | OpenAIRE |
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