Anatomically Defined and Functionally Distinct Dorsal Raphe Serotonin Sub-systems
| Autor: | Drew Friedmann, Tanya Weerakkody, Cindy D. Liu, Chen Ran, Brandon Weissbourd, Liqun Luo, Jing Xiong, Brielle R. Ferguson, Yanwen Sun, John R. Huguenard, Mark Horowitz, Jing Ren, Katherine E. DeLoach, Rachael L. Neve, Albert Pun |
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| Rok vydání: | 2018 |
| Předmět: |
Dorsal Raphe Nucleus
Male 0301 basic medicine Serotonin Population Anxiety Biology Serotonergic Amygdala Article General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Dorsal raphe nucleus Adaptation Psychological medicine Animals education 5-HT receptor Neurons education.field_of_study TPH2 Brain Frontal Lobe Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Forebrain Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell. 175:472-487.e20 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2018.07.043 |
| Popis: | The dorsal raphe (DR) constitutes a major serotonergic input to the forebrain and modulates diverse functions and brain states, including mood, anxiety, and sensory and motor functions. Most functional studies to date have treated DR serotonin neurons as a single population. Using viral-genetic methods, we found that subcortical- and cortical-projecting serotonin neurons have distinct cell-body distributions within the DR and differentially co-express a vesicular glutamate transporter. Further, amygdala- and frontal-cortex-projecting DR serotonin neurons have largely complementary whole-brain collateralization patterns, receive biased inputs from presynaptic partners, and exhibit opposite responses to aversive stimuli. Gain- and loss-of-function experiments suggest that amygdala-projecting DR serotonin neurons promote anxiety-like behavior, whereas frontal-cortex-projecting neurons promote active coping in the face of challenge. These results provide compelling evidence that the DR serotonin system contains parallel sub-systems that differ in input and output connectivity, physiological response properties, and behavioral functions. |
| Databáze: | OpenAIRE |
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