Photonic and magnetic materials for on-demand local drug delivery
| Autor: | Ilaria Armenia, Carlos Cuestas Ayllón, Beatriz Torres Herrero, Francesca Bussolari, Gabriel Alfranca, Valeria Grazú, Jesús Martínez de la Fuente |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Diputación General de Aragón, Fundação para a Ciência e a Tecnologia (Portugal), Instituto de Salud Carlos III, Consejo Superior de Investigaciones Científicas (España), Ministerio de Educación, Cultura y Deporte (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| ISSN: | 2020-1184 |
| Popis: | Nanomedicine has been considered a promising tool for biomedical research and clinical practice in the 21st century because of the great impact nanomaterials could have on human health. The generation of new smart nanomaterials, which enable time- and space-controlled drug delivery, improve the limitations of conventional treatments, such as non-specific targeting, poor biodistribution and permeability. These smart nanomaterials can respond to internal biological stimuli (pH, enzyme expression and redox potential) and/or external stimuli (such as temperature, ultrasound, magnetic field and light) to further the precision of therapies. To this end, photonic and magnetic nanoparticles, such as gold, silver and iron oxide, have been used to increase sensitivity and responsiveness to external stimuli. In this review, we aim to report the main and most recent systems that involve photonic or magnetic nanomaterials for external stimulus-responsive drug release. The uniqueness of this review lies in highlighting the versatility of integrating these materials within different carriers. This leads to enhanced performance in terms of in vitro and in vivo efficacy, stability and toxicity. We also point out the current regulatory challenges for the translation of these systems from the bench to the bedside, as well as the yet unresolved matter regarding the standardization of these materials. The research for this work has received funding from: grant PID2020-118485RB-I00 funded by Ministerio de Ciencia e Innovación/Agencia Estatal de Investigación, the European Union (EU) projects HOTZYMES (grant agreement n° 829162) and PRIME (grant agreement n° 829010) under EU’s Horizon 2020 Programme Research and Innovation actions H2020-FETOPEN-2018-2019-2020-01 and DGA and Fondos Feder (Bionanosurf E15_17R). This research was also supported by CIBER -Consorcio Centro de Investigación Biomédica en Red- (CB06/01/00263), Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación. This research work was also funded by the European Commission – NextGenerationEU (Regulation EU 2020/2094), through CSIC’s Global Health Platform (PTI Salud Global). F.B. also thanks Spanish MINECO project BIO2017-84246-C2-1-R for the FPI grant, G.A. is grateful for the Juan de la Cierva-formación (FJC2020-043450-I) funded by MCIN/AEI/ 10.13039/501100011033 and by “European Union NextGenerationEU/PRTR” and B.T. is grateful for the FPU predoctoral contract (FPU19/01311) from Ministerio de Educación Cultura y Deporte (Spain). |
| Databáze: | OpenAIRE |
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