Nuciferine prevents hepatic steatosis by regulating lipid metabolismin diabetic rat model
| Autor: | Guozhi Shen, Qian Ning, Zhenglu Xie, Jie Pang, Wang Yang, Yi Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Nuciferine endocrine system diseases QH301-705.5 medicine.medical_treatment nuciferine 030209 endocrinology & metabolism Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Gene expression lipid metabolism medicine diabetic Lipolysis Biology (General) chemistry.chemical_classification General Immunology and Microbiology General Neuroscience rat model hepatic steatosis Fatty acid nutritional and metabolic diseases Lipid metabolism medicine.disease 030104 developmental biology Endocrinology chemistry Lipogenesis Steatosis General Agricultural and Biological Sciences Adjuvant Research Article |
| Zdroj: | Open Life Sciences, Vol 14, Iss 1, Pp 699-706 (2019) Open Life Sciences |
| ISSN: | 2391-5412 |
| Popis: | ObjectiveThis study investigatesthe nuciferine capacity to regulate the liver’s lipid metabolism regarding steatosis and injury in STZ-induced diabetic rats.Materials and MethodsThe rats were randomly divided into groups control, diabetic and nuciferine 200 mg/kg/ day treatment. After 4 days of STZ injection, the nuciferine group was treated and administered via oral gavages for 4 weeks. At the end of experiment, blood, liver, myocardial and muscular samples were collected.ResultsNuciferine-treated significantly increased the body weight from 339.4g to 367.8g, but significantly decreased the food and water intake compared with diabetic rats. Also, the nuciferine-treated rats had significantly decreased TC, TG, and FFAs in the liver compared with the diabetic group, especially the serum markers of blood glucose. These were associated with the gene expression related to lipogenesis which was significantly down-regulated; the gene expression involved in lipolysis and fatty acid β-oxidation was significantly up-regulated. Discussion andConclusionThe data provide evidence that nuciferine supplementation could protect the liver by regulating lipid metabolism gene expression resulting in decreasing the steatosis and injury in diabetic rat. Thus, nuciferine could be developed as a diabetic adjuvant food additive in future. |
| Databáze: | OpenAIRE |
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