Enhanced Identification of Novel Potential Variants for Appendicular Lean Mass by Leveraging Pleiotropy With Bone Mineral Density
| Autor: | Xu Lin, Yu-Qian Song, Feng Liu, Qiao-Cong Chen, Cheng Peng, Hui-Ling Lou, Kuan-Jui Su, Jie Shen, Chun-Ping Zeng, Wen-Xi Li, Hong-Wen Deng, Hui-Hui Yuan, Shi-di Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine False discovery rate Male Immunology 030209 endocrinology & metabolism Genome-wide association study Single-nucleotide polymorphism Computational biology Biology Polymorphism Single Nucleotide 03 medical and health sciences 0302 clinical medicine appendicular lean mass Pleiotropy Bone Density pleiotropy Immunology and Allergy Humans Genetic variability KEGG Gene genome wide association study Original Research Bone mineral novel SNPs fungi Body Weight 030104 developmental biology Female lcsh:RC581-607 bone mineral density Genome-Wide Association Study |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Strong relationships have been found between appendicular lean mass (ALM) and bone mineral density (BMD). It may be due to a shared genetic basis, termed pleiotropy. By leveraging the pleiotropy with BMD, the aim of this study was to detect more potential genetic variants for ALM. Using the conditional false discovery rate (cFDR) methodology, a combined analysis of the summary statistics of two large independent genome wide association studies (GWAS) of ALM (n = 73,420) and BMD (n = 10,414) was conducted. Strong pleiotropic enrichment and 26 novel potential pleiotropic SNPs were found for ALM and BMD. We identified 156 SNPs for ALM (cFDR |
| Databáze: | OpenAIRE |
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