Heme-Oxygenase-1
Autor: | Maria Marta Facchinetti |
---|---|
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry INFLAMATION Inflammation Disease medicine.disease_cause Biochemistry Ciencias Biológicas 03 medical and health sciences Transcriptional regulation Medicine OXIDATIVE STRESS HEME OXYGENASE Molecular Biology General Environmental Science 030102 biochemistry & molecular biology business.industry Cancer Cell Biology Bioquímica y Biología Molecular medicine.disease CANCER Heme oxygenase 030104 developmental biology METABOLIC DISEASE Cancer cell HMOX1 Gene General Earth and Planetary Sciences medicine.symptom NEURODEGENERATIVE DISEASES business Neuroscience CIENCIAS NATURALES Y EXACTAS Oxidative stress |
Zdroj: | Antioxidants & Redox Signaling. 32:1239-1242 |
ISSN: | 1557-7716 1523-0864 |
DOI: | 10.1089/ars.2020.8065 |
Popis: | This Forum issue “Heme Oxygenase” (HO) includes original research articles and reviews that are aimed at understanding the role of HO-1 in several pathophysiological conditions, specially addressing those involving inflammation and oxidative damage. Overall, the seven contributions of this Forum highlight the dual role that HO-1 displays in cells and tissues, and address the molecular and cellular mechanisms through which HO-1 participates in the pathophysiology of the metabolic syndrome, obesity, cancer, and neurodegenerative, neurodevelopmental, and inflammatory bowel diseases. Indeed, one of the reviews thoroughly describes evidence of the anti-inflammatory properties of HO-1 in gut homeostasis, with potential to attenuate inflammatory bowel diseases. Three other reviews show the mostly beneficial effect of HO-1 expression in the attenuation of metabolic syndrome, obesity, cardiovascular disease, and diabetic cardiomyopathy. Contrariwise, one of the original articles show the overexpression of HO-1 in astroglia, models neurodegenerative (Parkinson-like) or neurodevelopmental (Schizophrenia-like) behaviors in mice, depending on the timing of expression of HO-1 during lifespan. The other original research communication demonstrates the role of HO-1 on the tropism of prostate cancer cells to bone, thus showing the involvement of this protein in the communication between bone and cancer cells. Finally, the Forum issue includes a review that elaborates on the classic and ultimate knowledge of HO-1 transcriptional regulation as well as the mechanisms of alternative splicing and post-transcriptional regulation of Hmox1 gene expression that have been little explored. Fil: Facchinetti, Maria Marta. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur. Instituto de Investigaciones Bioquímicas de Bahía Blanca; Argentina |
Databáze: | OpenAIRE |
Externí odkaz: |