The impact of genetic variants on BMI increase during childhood versus adulthood

Autor: Paolo Piaggi, Maximilian G. Hohenadel, Yunhua L. Muller, Jonathan Krakoff, Robert L. Hanson, Leslie J. Baier, Marie S. Thearle
Rok vydání: 2015
Předmět:
0301 basic medicine
Male
Health Knowledge
Attitudes
Practice
Preschool Female Genetic Predisposition to Disease/epidemiology *Genetic Variation Genotype Health Knowledge
Single Nucleotide Young Adult
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Body Mass Index
0302 clinical medicine
Medicine
Adolescent Adult Alleles Arizona/epidemiology Body Composition/genetics *Body Mass Index Child Child
Longitudinal Studies
Young adult
Child
Nutrition and Dietetics
Framingham Risk Score
Arizona
Middle Aged
Child
Preschool
Body Composition
Female
medicine.symptom
Practice Humans Indians
Adult
medicine.medical_specialty
Adolescent
Genotype
030209 endocrinology & metabolism
Single-nucleotide polymorphism
Polymorphism
Single Nucleotide
Article
03 medical and health sciences
Young Adult
Internal medicine
Humans
Genetic Predisposition to Disease
Obesity
North American/*genetics Longitudinal Studies Male Middle Aged Obesity/epidemiology/*genetics/prevention & control Polymorphism
Alleles
business.industry
Repeated measures design
Genetic Variation
medicine.disease
Confidence interval
030104 developmental biology
Endocrinology
Attitudes
Adolescent Adult Alleles Arizona/epidemiology Body Composition/genetics *Body Mass Index Child Child
Preschool Female Genetic Predisposition to Disease/epidemiology *Genetic Variation Genotype Health Knowledge
Attitudes
Practice Humans Indians
North American/*genetics Longitudinal Studies Male Middle Aged Obesity/epidemiology/*genetics/prevention & control Polymorphism
Single Nucleotide Young Adult
Indians
North American
business
Body mass index
Weight gain
Demography
Zdroj: Int J Obes (Lond)
ISSN: 1476-5497
Popis: BACKGROUND: Genetic variants that predispose individuals to obesity may have differing influences during childhood versus adulthood, and additive effects of such variants are likely to occur. Our ongoing studies to identify genetic determinants of obesity in American Indians have identified 67 single-nucleotide polymorphisms (SNPs) that reproducibly associate with maximum lifetime non-diabetic body mass index (BMI). This study aimed to identify when, during the lifetime, these variants have their greatest impact on BMI increase. SUBJECTS/METHODS: A total of 5906 Native Americans of predominantly Pima Indian heritage with repeated measures of BMI between the ages of 5 and 45 years were included in this study. The association between each SNP with the rates of BMI increase during childhood (5–19 years) and adulthood (20–45 years) were assessed separately. The significant SNPs were used to calculate a cumulative allelic risk score (ARS) for childhood and adulthood, respectively, to assess the additive effect of these variants within each period of life. RESULTS: The majority of these SNPs (36 of 67) were associated with rate of BMI increase during childhood (P-value range: 0.00004–0.05), whereas only nine SNPs were associated with rate of BMI change during adulthood (P-value range: 0.002–0.02). These 36 SNPs associated with childhood BMI gain likely had a cumulative effect as a higher childhood-ARS associated with rate of BMI change (β = 0.032 kg m(−2) per year per risk allele, 95% confidence interval: 0.027–0.036, P
Databáze: OpenAIRE
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