A nomenclature system for labeling cyclic peptide fragments
| Autor: | Michael L. Gross, Lambert C. M. Ngoka |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
chemistry.chemical_classification
Chemical Phenomena Chemistry Physical Stereochemistry 010401 analytical chemistry Peptide 010402 general chemistry Mass spectrometry 01 natural sciences Mass Spectrometry Cyclic peptide 0104 chemical sciences Amino acid Residue (chemistry) chemistry.chemical_compound chemistry Structural Biology Terminology as Topic Amide Moiety Peptides Spectroscopy Bond cleavage |
| Zdroj: | Journal of the American Society for Mass Spectrometry. 10:360-363 |
| ISSN: | 1044-0305 |
| DOI: | 10.1016/s1044-0305(99)00006-9 |
| Popis: | A nomenclature system for labeling fragment ions of cyclic peptides is proposed. A fragment ion is labeled with a four-part descriptor of the general formula xnJZ, where x is the designation for the ion (e.g., lower case a or b, as are used for peptide fragments) and n is the number of amino acid residues in the ion. A b ion is the usual acylium ion or isomeric equivalent consisting of n amino-acid residues, and this ion may lose carbon monoxide to form an a ion. The subscripts J and Z are the one-letter (upper-case) codes for the two amino-acid residues connecting the backbone amide or ester bond, J–Z, that can be viewed as broken to form the decomposing linear ion. The symbol J is for the N-terminal amino-acid residue, and Z is that for the C-terminal amino-acid residue that result from the bond cleavage. The nomenclature system is applicable to a wide range of cyclic peptides, including depsipeptides, cyclic peptides containing modified or unusual amino acids, cyclic peptides bearing a linear peptide moiety, and cyclic peptides that are introduced into the gas phase as metal–ion cationized species. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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