Atrial natriuretic peptide inhibits ovarian functions in female mice
| Autor: | Yong-Yu Yang, Eing-Mei Tsai, Yu Chang, Tony Tong-Yin Lee, Shelly Li, Jau-Nan Lee |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Ovulation
endocrine system medicine.medical_specialty Menotropins Ratón media_common.quotation_subject medicine.medical_treatment Cell Count Ovary Chorionic Gonadotropin Mice Ovarian Follicle Atrial natriuretic peptide Internal medicine Follicular phase medicine Animals Ovarian follicle Saline Progesterone media_common Diminution Mice Inbred ICR Estradiol business.industry Obstetrics and Gynecology Organ Size Luteinizing Hormone medicine.anatomical_structure Endocrinology Reproductive Medicine Pituitary Gland Oocytes Female Follicle Stimulating Hormone Peritoneum business Atrial Natriuretic Factor hormones hormone substitutes and hormone antagonists |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 119:215-218 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2004.09.005 |
| Popis: | Objective: To investigate the effects of atrial natriuretic peptide (ANP) on ovarian regulation in mice through intraperitoneal administration. Study design: Forty-two ICR strain female mice were divided into seven groups, including one control. Each mouse received ovarian hyperstimulation. ANP was prepared with saline at concentrations of 0 (as control), 2, 4, 8, 10, 20, and 30ng/g of body weight. The solution was intraperitoneally applied to each referred group ( n =6) 1h before the hMG and hCG injections. The mice were sacrificed next morning and blood samples were collected for analysis. Results: A significant reduction in both ovarian weight and the number of oocytes was found as the ANP dosage increased. ANP treatment decreased both serum estradiol and progesterone levels. The pituitary FSH and LH contents elevated significantly by ANP at a dosage larger than 4ng/g of body weight; however, both serum FSH and LH levels remained unchanged. Histologically, there were remarkable ovarian inhibitory features, i.e. reduction in size and number of follicles, arrest of follicular growth and diminution of ovulation. Conclusion: Intraperitoneal administration of ANP inhibits the follicular growth, ovulation and steroidogenesis in female mice. These effects are attributed to the direct action of ANP on ovaries. |
| Databáze: | OpenAIRE |
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