Disruption of lateral hypothalamic calorie detection by a free choice high fat diet
| Autor: | Ian M. Linville, Mireille J. Serlie, Margo Slomp, Serge Luquet, Laura L. Koekkoek, Susanne E. la Fleur, Julien Castel, Michael E. Mutersbaugh |
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| Přispěvatelé: | University of Amsterdam [Amsterdam] (UvA), Royal Netherlands Academy of Arts and Sciences (KNAW), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of Virginia, Luquet, Serge, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), University of Virginia [Charlottesville], Graduate School, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Neuroscience - Brain Imaging, Laboratory for Endocrinology, Endocrinology |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Sucralose Calorie Lateral hypothalamus Saturated fat [SDV]Life Sciences [q-bio] glutamate Diet High-Fat Biochemistry 03 medical and health sciences Glutamatergic chemistry.chemical_compound Mice 0302 clinical medicine Calcium imaging Internal medicine Genetics medicine Animals two-photon microscopy hypothalamus Molecular Biology Diet Fat-Restricted 030304 developmental biology 0303 health sciences Chemistry digestive oral and skin physiology Caloric theory food and beverages calorie detection Mice Inbred C57BL [SDV] Life Sciences [q-bio] Endocrinology Hypothalamus Hypothalamic Area Lateral Sweetening Agents Female low-calorie sweetener Energy Intake 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | FASEB Journal FASEB Journal, 2021, 35 (9), ⟨10.1096/fj.202100762r⟩ FASEB Journal, Federation of American Society of Experimental Biology, 2021, 35 (9), ⟨10.1096/fj.202100762r⟩ FASEB journal, 35(9):e21804. FASEB |
| ISSN: | 0892-6638 1530-6860 |
| DOI: | 10.1096/fj.202100762r⟩ |
| Popis: | International audience; During the last few decades, the consumption of low-calorie sweeteners, as a substitute for caloric sweeteners, has sharply increased. Although research shows that caloric versus low-calorie sweeteners can have differential effects on the brain, it is unknown which neuronal populations are responsible for detecting the difference between the two types of sweeteners. Using in vivo two-photon calcium imaging, we investigated how drinking sucrose or sucralose (a low-calorie sweetener) affects the activity of glutamatergic neurons in the lateral hypothalamus. Furthermore, we explored the consequences of consuming a free-choice high fat diet on the calorie detection abilities of these glutamatergic neurons. We found that glutamatergic neurons indeed can discriminate sucrose from water and sucralose, and that consumption of a free-choice high fat diet shifts the glutamatergic neuronal response from sucrose-specific to sucralose-specific, thereby disrupting calorie detection. These results highlight the disruptive effects of a diet high in saturated fat on calorie detection in the lateral hypothalamus. |
| Databáze: | OpenAIRE |
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