Control of phenotypic expression of cultured melanoma cells by melanocyte stimulating hormones
| Autor: | Glenda Wong, John M. Pawelek |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Melanocyte-stimulating hormone Transcription Genetic Biology Tritium General Biochemistry Genetics and Molecular Biology Cell Line Melanin Tissue culture Mice Internal medicine medicine Cyclic AMP Animals Melanocyte-Stimulating Hormones RNA Neoplasm Cycloheximide Melanoma Melanins integumentary system General Medicine Metabolism DNA Neoplasm Neoplasms Experimental medicine.disease Phenotype Adenosine Cell biology Butyrates Endocrinology Cell culture Protein Biosynthesis Dactinomycin hormones hormone substitutes and hormone antagonists Catechol Oxidase Cell Division medicine.drug |
| Zdroj: | Nature: New biology. 241(111) |
| ISSN: | 0090-0028 |
| Popis: | STUDIES of the mechanism through which MSH acts in mammals have been restricted to intact animals or to melanomas grown in animals1,2. We describe here a mouse melanoma cell line cultivated in monolayer which when exposed to MSH shows large increases in tyrosinase activity and melanin content, as well as changes in growth characteristics and cellular morphology. In addition, we have found that adenosine 3',5'-monophosphate (cyclic AMP) or its analogue N6,O2'-dibutyryl cyclic AMP (diB cyclic AMP) will substitute for MSH, supporting previous evidence that MSH probably acts through cyclic AMP in mammals1,3. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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