Scintigraphic Evaluation of a New Capsule-Type Colon Specific Drug Delivery System in Healthy Volunteers
| Autor: | G.R. Pitcairn, T. Ishibashi, Masakazu Mizobe, Hiroyuki Yoshino, I.R. Wilding |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Colon Pharmaceutical Science Capsules Pharmacology Colon specific Scintigraphy Drug Delivery Systems Animal model Healthy volunteers medicine Humans Enteric coated Gastrointestinal Transit Radionuclide Imaging Radioisotopes Samarium Cross-Over Studies Gastric emptying medicine.diagnostic_test business.industry Capsule Fasting Postprandial Period Surgery Drug delivery business |
| Zdroj: | Journal of Pharmaceutical Sciences. 87:531-535 |
| ISSN: | 0022-3549 |
| DOI: | 10.1021/js9704588 |
| Popis: | □ Colonic drug delivery is intended for local or systemic therapies. The lack of predictive in vitro or animal model leads to considerable time delays in colonic product development. The objective of this scintigraphic study was to provide “proof of concept” for a novel capsule-type colonic delivery system (Colon-Targeted Delivery Capsule) in healthy volunteers. The human data validates the design concept behind the release mechanism, in that capsule disintegration, and hence drug release, did not start until 5 h after gastric emptying, irrespective of whether the product was administered to fasted or fed subjects. However, the potential for prolonged gastric residence for large enteric coated products intended for intestinal targeting was also observed; overall, the study provides a focus for subsequent product development and highlights the role of scintigraphy in dynamically visualizing the drug delivery process. |
| Databáze: | OpenAIRE |
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