Allogeneic hepatocyte transplantation: Contribution of Fas-Fas ligand interaction to allogeneic hepatocyte rejection
| Autor: | Hideo Yagita, Masayuki Sawa, Shunji Futagawa, Michio Mito, Kazuya Kato, Toshiyasu Kawahara, Shinichi Kasai, Kyoko Okumura |
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| Rok vydání: | 1998 |
| Předmět: |
Graft Rejection
Fas Ligand Protein medicine.drug_class medicine.medical_treatment Ligands Monoclonal antibody Fas ligand 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Transplantation Homologous fas Receptor Membrane Glycoproteins Hepatology business.industry Gastroenterology Immunosuppression Liver Transplantation Transplantation surgical procedures operative medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocyte Immunology 030211 gastroenterology & hepatology Hepatocyte growth factor business CD80 medicine.drug |
| Zdroj: | Journal of Gastroenterology and Hepatology. 13:S119-S123 |
| ISSN: | 0815-9319 |
| DOI: | 10.1111/jgh.1998.13.s1.119 |
| Popis: | Hepatocyte transplantation is a potential therapeutic modality for overcoming the shortage of liver donors, and the clinical application of allogeneic hepatocyte transplantation has been considered. However, there are two major problems with allogeneic hepatocyte transplantation: protection of transplanted hepatocytes from rejection and stimulation of the rapid proliferation of surviving cells. Without immunosuppression, allogeneic hepatocytes are rapidly rejected within a few days after transplantation, even though it is relatively easy to induce immunotolerance after allogeneic whole liver transplantation. Accordingly, different rejection mechanisms seem to operate after allogeneic hepatocyte transplantation and whole liver transplantation. To overcome the rejection of transplanted hepatocytes, induction of donor-specific unresponsiveness to graft without compromising the host immune system would be ideal. We previously reported that the Fas-Fas ligand system plays a critical role in the CD28-independent pathway of hepatocyte rejection. Therefore, blockade of rejection using CTLA4 immunoglobulin (CTLA4Ig) or anti-CD80/86 monoclonal antibodies and anti-FasL monoclonal antibody may prolong the survival of transplanted allogeneic hepatocytes. Furthermore, administration of hepatocyte growth factor (HGF) can promote the proliferation of allogeneic hepatocytes and this may lead to the development of a functioning liver substitute. |
| Databáze: | OpenAIRE |
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