Serotonin contributes to the spinal antinociceptive effects of morphine
| Autor: | Janet L. Stafinsky, Terriann Crisp, Marc Uram, Linda J. Spanos, Veeraiah C. Perni, Michael F. Weaver |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Adrenergic Antagonists Serotonin medicine.medical_specialty Clinical Biochemistry Ritanserin Pharmacology Toxicology Serotonergic Biochemistry Behavioral Neuroscience chemistry.chemical_compound Internal medicine Reaction Time Animals Medicine Biogenic Monoamines Adrenergic alpha-Antagonists Injections Spinal Biological Psychiatry 5-HT receptor Nerve Endings Analgesics Dose-Response Relationship Drug Morphine business.industry Rats Inbred Strains Naltrexone Rats Spiroxatrine Nociception Endocrinology Spinal Cord chemistry Opioid Receptors Opioid Serotonin Antagonists Opiate business medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 39:591-595 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(91)90133-m |
| Popis: | This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats were fitted with IT catheters. One week later, animals were spinally pretreated with receptor antagonists selective for opioid, serotonin or α-adrenoceptors, and the ability of these agents to alter spinal morphine-induced antinociception was assessed. Morphine dose-dependently elevated tail-flick latency in a naltrexone-reversible manner. The serotonin receptor antagonists spiroxatrine (5-HT 1A ), pindolol (5-HT 1B ), ritanserin (5-HT 2 ) and ICS 205–930 (5-HT 3 ) attenuated the spinal analgesic effects of morphine. In contrast, the α 1 and α 2 -adrenoceptor antagonists prazosin and yohimbine, respectively, did not alter morphine-induced elevations in tail-flick latency. These data substantiate earlier reports that spinal morphine-induced antinociception relies on an opioid receptor-mediated component in addition to a local serotonergic component. The finding that the α-adrenoceptor antagonists did not alter the antinociceptive effects of IT morphine suggests that spinal norepinephrine does not contribute to the analgesic effects of the opiate. |
| Databáze: | OpenAIRE |
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