Indications and diagnostic value of bone marrow examination in HIV-positive individuals: A 3-year review at Tygerberg Hospital
| Autor: | Fatima Alzanad, Robert K. Lohlun, Ibtisam Abdullah, Ernest Musekwa, Ethan Gantana, Erica-Mari Nell, Zivanai C. Chapanduka, Wardah Cerfontein, Bridget Cochrane, Carissa Chetty, Nadhiya Subramony |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Human immunodeficiency virus (HIV) Pure red cell aplasia lymphoma Infectious and parasitic diseases RC109-216 investigation of cytopenia medicine.disease_cause Asymptomatic bone marrow examination Interquartile range Internal medicine hemic and lymphatic diseases medicine Original Research diagnostic utility Cytopenia indications medicine.diagnostic_test business.industry HIV medicine.disease Lymphoma Bone marrow examination medicine.anatomical_structure diagnostic yield leukaemia Bone marrow medicine.symptom business |
| Zdroj: | Southern African Journal of Infectious Diseases Southern African Journal of Infectious Diseases, Vol 36, Iss 1, Pp e1-e7 (2021) |
| ISSN: | 2313-1810 |
| Popis: | Background: Bone marrow examination is a useful diagnostic tool in human immunodeficiency virus (HIV)-positive patients presenting with cytopenias and fever. However, its role in the afebrile and asymptomatic patient presenting with an isolated cytopenia is not well established. This study was conducted to determine the indications for bone marrow examination and its diagnostic yield, in HIV-positive patients at Tygerberg Hospital.Methods: A retrospective, cross-sectional descriptive study was performed over a 3-year period from 01 September 2015 to 31 August 2018. The bone marrow examination reports for the HIV-positive patients who had a bone marrow examination during the study period were retrieved. Clinical and laboratory information was captured.Results: Altogether 374 bone marrow reports for HIV-positive patients were found. The indication of the bone marrow examination included investigation of unexplained cytopenias, suspected haematological malignancies, follow-up examination for patients with known haematological diseases, staging of haematological or non-haematological malignancies and investigation of suspected disseminated infection. The patients’ median age was 43 years and the interquartile range was 27–60 years. There was a slight female predominance with females 51% and males 49%. The diagnostic yield was 33.7%. Acute leukaemia and lymphoma were the most common diagnoses. Haematinic deficiency and pure red cell aplasia were found in the majority of cases with isolated anaemia. All cases with isolated thrombocytopenia were due to immune thrombocytopenia.Conclusion: Bone marrow examination is a useful investigation for HIV-positive patients with cytopenias, suspected haematological malignancy and lymphoma staging. However, its early use in patients with isolated anaemia and isolated thrombocytopenia is questionable. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|